IN A finding that sheds new light on the ageing process, scientists have discovered that men who father children later in life are more likely to produce daughters who have a shorter lifespan. A study of European royal families, including the House of Windsor, discovered that men who have children in late middle age are more likely to have daughters who die earlier in life than the daughters of...

An altered pattern of epigenetic modifications is central to many common human diseases, including cancer. Many studies have explored the mosaic patterns of DNA methylation and histone modifications in cancer cells on a gene-by-gene basis, among them the seminal finding of transcriptional silencing of tumor suppressor genes by CpG island promoter hypermethylation. Epigenetic gene inactivation i...

mind, including mental illness. It is a fair sample of the level of the writing throughout the issue, which is clear, informative, balanced, critical, and, above all, responsible. Since mind-trouble is far and away the commonest, and one of the most distressing, of human afflictions, there is a large and ready readership for writings on the theme. The whole subject is so highly emotive, and the...

Transport of synaptic components is a regulated process. Loss-of-function mutations in the C. elegans unc-16 gene result in the mislocalization of synaptic vesicle and glutamate receptor markers. unc-16 encodes a homolog of mouse JSAP1/JIP3 and Drosophila Sunday Driver. Like JSAP1/JIP3, UNC-16 physically interacts with JNK and JNK kinases. Deletion mutations in Caenorhabditis elegans JNK and JN...

Sunday in the Park with George was inspired by Georges Seurat’s famous painting, A Sunday Afternoon on the Island of La Grande Jatte and is one of the most critically acclaimed musicals of our time. Sunday is a dramatic visual and musical masterwork. It’s also a deeply moving love story that connects the past to the future through passionate and intensely personal struggles that are not unlike ...

Exhibitions Dates to note are: Sunday, 21st November 1999. West of England Creepy Crawly Show, Newton Abbot racecourse, Devon. Sunday, 5th December 1999. Midlands Entomological Fair. At Kettering Leisure Village. Open 1030-1630. Admission: £2.00 adults, £1.00 children and OAPs. The venue is just off junction 8 of the A14 and is usually well signposted. Sunday 16th April 2000. Midlands Entomolog...