By H. G. PETERING, PH.D., R. A. DELOR, B.S., AND H. C. MURRAY, PH.D. F OLIC acid or vitamin B9 deficiency has been induced in the rat by feeding a purified diet containing succinyl sulfathiazole or sulfaguanidine)’2’3’4’5’6 This deficiency is corrected in either case by feeding free or conjugated pteroyl glutamic acid while the syndrome produced by sulfaguanidine is also corrected by paraaminob...

Recommended Citation Qiu, Yang. "Dissolution mechanisms: theoretical and experimental investigations. ABSTRACT Dissolution rate is an important indicator of drug bioavailability. In this work, a mixed-kinetic-controlled dissolution model was developed which encompasses transport control and interface control as limiting cases. This model is mathematically equivalent to two existing mixed-kineti...

In 1940 Russell and Falconer2 reported that no appreciable damage had been sustained by the cortex or leptomeninges of the rabbit's brain when exposed for a period of four days to soluseptasine or to finely powdered sulfanilamide and sulfapyridine. The drugs were applied to the surface of the cortex and were also introduced into the subcortical tissues. A mild inflammatory reaction occurred, wh...

This investigation was initiated to determine the optimal dose of oral peniciin required to give a satisfactory peniillin blood level in infants under a month old and to compare the relative efficcy of picillin and sulphathiazole paste in the treatment of minor skin lesions in infants during the neonatal period. The obvious advanta of penillin over other drugs are counterbalanced by the discomf...

Design and synthesis of two sulfathiazole derivatives using a three-component system L. Figueroa-Valverde, F. Díaz-Cedillo, E. García-Cervera, E. Pool Gómez, M. RosasNexticapa, M. López-Ramos Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P.24039 Campeche Cam., México. Escuela Nac...

The application of Pd/Fe3O4 nanoparticles (NPs) for the adsorption of sulfathiazole from urine samples prior to high performance liquid chromatography-ultraviolet detection was studied. Pd/Fe3O4 NPs were synthesized using plant extract. Possible impact parameters in the extraction process such as the magnetic adsorbents amount, extraction time, sample pH and desorption conditions were investiga...