in vivo and in vitro sublethal exposure of abrin, glycyrrhizin (active component of abrus precatorius seed and root), sanguinarine, protopine (argemone mexicana seed) and oleandrin (nerium indicum leaf) inhibited the acetylcholinesterase, lactic dehydrogenase, acid and alkaline phosphatase activity in the nervous tissue of lymnaea acuminata. the succinic dehydrogenase activity in the nervous ti...

Sixty samples of pleural fluid from 52 patients were subjected to direct gas-liquid chromatographic studies, and results were correlated with findings from microbiologic cultures. Fourteen patients had anaerobic empyema, 22 had aerobic infections, and 16 had sterile pleural effusions. Multiple volatile fatty acids or succinic acid or both were found as markers of anaerobic infection in all but ...

The water-vapor interface of aqueous solutions of succinic acid, where pH values and bulk concentrations were varied, has been studied using surface sensitive X-ray photoelectron spectroscopy (XPS) and molecular dynamics (MD) simulations. It was found that succinic acid has a considerably higher propensity to reside in the aqueous surface region than its deprotonated form, which is effectively ...

BACKGROUND Animal experiments revealed that succinylcholine produced masseter muscle rigidity and activated myotonic discharges despite neuromuscular blockade with a nondepolarizing blocker. These results suggest that either succinylcholine or its metabolites might interfere directly with voltage-operated ion channels of the sarcolemma. The aim of this study was to examine effects of one produc...

As a potential intermediary feedstock, succinic acid takes an important place in bulk chemical productions. For the first time, a method combining Plackett-Burman design (PBD), steepest ascent method (SA), and Box-Behnken design (BBD) was developed to optimize Actinobacillus succinogenes ATCC 55618 fermentation medium. First, glucose, yeast extract, and MgCO(3) were identified to be key medium ...

Biorefinery, an example of a multiple products system, integrates biomass conversion processes and equipment to produce fuels, power and chemicals from biomass. This study focuses on technical design, economic and environmental analysis of a lignocellulosic feedstock (LCF) biorefinery producing ethanol, succinic acid, acetic acid and electricity. As the potential worldwide demand of succinic ac...

The mechanisms and kinetics of unimolecular decomposition of succinic acid and its anhydride have been studied at the G2M(CC2) and microcanonical RRKM levels of theory. It was shown that the ZsgsZ conformer of succinic acid, with the Z-acid form and the gauche conformation around the central C-C bond, is its most stable conformer, whereas the lowest energy conformer with the E-acid form, ECGsZ,...

This paper presents a study on gene knockout strategies to identify candidate genes to be knocked out for improving the production of succinic acid in Escherichia coli. Succinic acid is widely used as a precursor for many chemicals, for example production of antibiotics, therapeutic proteins and food. However, the chemical syntheses of succinic acid using the traditional methods usually result ...

Succinic acid has been favored by researchers due to its industrial multi-uses. However, the production of succinic acid is far below cell theoretical maximum. The goal of this research is to identify the optimal set of gene knockouts for obtaining high production of succinic acid in microorganisms. Gene knockout is a widely used genetic engineering technique. Hence, a hybrid of Harmony Search ...

BACKGROUND Succinic acid is one of the key platform chemicals which can be produced via biotechnology process instead of petrochemical process. Biomass derived bio-oil have been investigated intensively as an alternative of diesel and gasoline fuels. Bio-oil could be fractionized into organic phase and aqueous phase parts. The organic phase bio-oil can be easily upgraded to transport fuel. The ...