Since the original observations of Meynet (1) and Barlow and Warner (2) on the occurrence of subcutaneous nodules in rheumatic fever, numerous studies on these lesions have appeared. I t is now well recognized that subcutaneous nodules are a frequent manifestation of the disease rheumatic fever and that these lesions present a highly characteristic histological structure. Occasional reference (...

Gouty panniculitis is a rare manifestation of gout. Clinically, it is characterized by indurated subcutaneous nodules in nonjoint areas. Pathologically, typical characteristic gouty tophi can be seen in subcutaneous tissue. It is postulated that gouty panniculitis develops as a consequence of uric acid accumulation in the body and localized inflammatory changes in subcutaneous tissue. We report...

The observations of Collins (1937) and of Bennett, Zeller, and Bauer (1940) established clearly the pathological differentiation of the ordinary subcutaneous nodules in rheumatic fever and in rheumatoid arthritis. In brief, the rheumatic fever nodule is characterized by much fibrinoid material arranged in a lattice with apparently clear spaces between the strands, considerable oedema, but relat...

INTRODUCTION Cysticercosis is the larval manifestation of the cestode T. solium. It commonly presents as subcutaneous and intramuscular nodules which is often clinically misinterpreted as benign mesenchymal lesions and lymph nodes. Cysticerci in subcutaneous nodules can be diagnosed rapidly and with considerable accuracy by FNAC. This study highlights the cytomorphological features of subcutane...

Nodules obtained from five patients with classical seropositive rheumatoid arthritis were studied by an immunofluorescence technique using polyclonal antibodies to IgG, IgA, IgM, C3c, and fibrin, and monoclonal antibodies to the terminal (C5b-9) complement complex (reaction with a neoantigen in C9 revealed during activation), DR antigens, T cells, macrophages, and interdigitating cells. In all ...

A 29 year old male with rheumatoid arthritis (RA) of 10 years duration presented with multiple subcutaneous nodules of one month duration while on methotrexate (7.5 mg once a week), salazopyrine (1000 mg/day) and methyl prednisolone (4 mg/day). The nodules involved tendons of metacarpophalangeal joints (Figure 1) and base of left great toe (Figure 2), were painless and did not interfere with hi...