This nationwide prospective study was designed to determine prognostic factors and evaluate the outcome of different treatments of Perthes' disease. A total of 28 hospitals in Norway were instructed to report all new cases of Perthes' disease over a period of five years and 425 patients were reported and followed for five years. Of these, 368 with unilateral disease were included in the present...

isomorphous replacements, for clarification and possible decision among the several structures proposed. tRNA has long been known to be rich in minor base modifications (6, 20), of which the most common is methylation, and this occurs on all 4 major bases. Data presented at this symposium by Stulberg and Shugart (72) support the logical inference that these base modifications change the tertiar...

We performed a paired study of mature patients with Perthes' disease to compare the radiological results after treatment between conservatively- and surgically-treated groups. One patient was selected from each group to create the pairs for this study. Each pair was strictly matched for gender, body mass index, age at onset, stage at the first visit, necrotic area and radiological at-risk signs...

The aim of the study was to retrospectively review results of operative treatment for coverage deficit of femoral head in children with severe epiphysis displacement in Legg-Calvé-Perthes (LCP) disease. The material included 23 shelf acetabuloplasty procedures for LCP disease. The average age at diagnosis was 8.1 years (range 4-12). Mean follow-up was 5.8 years (range from 2.2 to 11.2 years). M...

The deformity index is a new radiological measurement of the degree of deformity of the femoral head in unilateral Perthes' disease. Its values represent a continuous outcome measure of deformity incorporating changes in femoral epiphyseal height and width compared with the unaffected side. The sphericity of the femoral head in 30 radiographs (ten normal and 20 from patients with Perthes' disea...

In 1910, Legg, Calvé and Perthes described almost simultaneously the major features of a disease, which was, by that time, confused with hip tuberculosis. The disease is described as a self-limiting disorder affecting the hip, and is characterized by total or partial aseptic necrosis of the femoral head, yielded by blood supply interruption, followed by subchondral fracture, revascularization a...

BACKGROUND Multiple epiphyseal dysplasia (MED) is a relatively common skeletal dysplasia mainly involving the epiphyses of the long bones. However, it is a genetically heterogeneous group of diseases sharing certain aspects of the radiologic phenotype. In surveys conducted in East Asia, MATN3 was the most common causative gene, followed by COMP. In this study, the authors compared clinical mani...

Technical Papers The Elucidation of Biocytin: Lemuel D. Wright et al. 635 The Function of the Cups of Polyporus conchifer: Harold J. Brodie ._ 636 Volatile Silica Affecting Plant Ash Analyses: Frank Liebenthal _ 636 Silicone Water-Repellents for General Use in the Laboratory: Paul T. Gilbert, Jr. _ 637 Multiplication of Rickettsia tsutsugamushi and Ornithosis Virus in Transplantable Mouse Tumor...

Technical Papers The Elucidation of Biocytin: Lemuel D. Wright et al. 635 The Function of the Cups of Polyporus conchifer: Harold J. Brodie ._ 636 Volatile Silica Affecting Plant Ash Analyses: Frank Liebenthal _ 636 Silicone Water-Repellents for General Use in the Laboratory: Paul T. Gilbert, Jr. _ 637 Multiplication of Rickettsia tsutsugamushi and Ornithosis Virus in Transplantable Mouse Tumor...

An assay system in vitro for the growth of malignant lymphoblastic colony-forming cells (CFC) was established. Growth of malignant myeloblastic CFC has been previously reported, but this is the first report of growth of malignant lymphoblastic CFC. Established assay systems in vitro have been very helpful in elucidating the control of growth and differentiation of both normal and malignant bone...