Recent successes in clinical trials have provided important proof of concept that small interfering RNAs (siRNAs) indeed constitute a new promising class of therapeutics. Although great efforts are still needed to ensure efficient means of delivery in vivo, the siRNA molecule itself has been successfully engineered by chemical modification to meet initial challenges regarding specificity, stabi...

Chromatin is subject to proofreading and repair mechanisms during the process of DNA replication, as well as repair to maintain genetic and epigenetic information and genome stability. The dynamic structure of chromatin modulates various nuclear processes, including transcription and replication, by altering the accessibility of the DNA to regulatory factors. Structural changes in chromatin are...

Musicians make use of the notion of shape in relation to music performance, teaching, composition, improvisation; they often think and talk about the shape of a musical phrase or melody, the shape of a single sound event, the shape of a longer section or piece, the expressive shaping of music during performance. But how can a primarily spatial term such as shape (meaning “the external form, con...

In general, mechanical equipment such as cars, airplanes, and machine tools all operate with constant frequency characteristics. These constant working characteristics should be controlled if the dynamic performance of the equipment demands improvement or the dynamic characteristics is intended to change with different working conditions. Active control is a stable and beneficial method for thi...

introduction and objective: alport’s syndrome (hereditary nephritis with deafness) is a familial uncommon disease that ultra-structural studies are gold standard method of its diagnosis. materials and methods:we studied 26 iranian patients suspicious of alport’s syndrome by electron microscopy. we examined 19 men and 7 women (male to female ratio was 2.7) and the average age was 1.5 years (with...