Preventing stress gastropathy has been a mainstay in the management of critically ill patients for decades. A landmark trial in 1994 identified the most significant risk factors for stress gastropathy as mechanical ventilation for greater than 48 h and primary coagulopathy. Since this study's publication more than two decades ago, the incidence of clinically significant gastrointestinal bleedin...

OBJECTIVE To assess the cost-effectiveness of prophylaxis for stress-related gastrointestinal hemorrhage in patients admitted to the intensive care unit. DESIGN Decision model of the cost and efficacy of sucralfate and cimetidine, two commonly used drugs for prophylaxis of stress-related hemorrhage. Outcome estimates were based on data from published studies. Cost data were based on cost of m...

BACKGROUND Despite the scanty data, proton pump inhibitors (PPI) are widely used for stress-related mucosal disease (SRMD) prophylaxis. There were few studies using PPI for SRMD prophylaxis but the results were conflicting, most probably due to inadequate sample size. The present meta-analysis aimed to determine the efficacy of PPI, as compared to histamine-2 receptor antagonists (H2RA) in the ...

INTRODUCTION Needlestick injury or mucosal contact with blood or body fluids is well recognised in the health care setting. This study aimed to describe the post-exposure management and outcome in health care workers following exposure to hepatitis B, hepatitis C, or human immunodeficiency virus (HIV) during needlestick injury or mucosal contact. METHODS This case series study was conducted i...

Background & AimsThe risk of recurrence Crohn’s disease (CD) from 1 to 10 years after surgery despite initial endoscopic remission (late post-operative recurrence) is not clear.MethodsWe performed a retrospective study, at 3 inflammatory bowel (IBD) centers in France and Belgium, all patients with CD (n = 86) undergoing an ileocecal resection curative intent 2006 through 2016 who did have evide...

Ribosome-inactivating (ribotoxic) xenobiotics are capable of using cleavage and modification to damage 28S ribosomal RNA, which leads to translational arrest. The blockage of global protein synthesis predisposes rapidly dividing tissues, including gut epithelia, to damage from various pathogenic processes, including epithelial inflammation and carcinogenesis. In particular, mucosal exposure to ...

Oral lichen planus is a chronic non-infectious mucosal inflammatory disease caused by an imbalance between reactive oxygen species homeostasis and antioxidant defense systems. Notably, excessive oxidative stress products result in related autoimmune reactions. Further, it activates signaling pathways to the development of oral planus, as evidenced detection damage deoxyribonucleic acid, protein...

A. Study Purpose and Rationale The most recent guidelines available on stress ulcer prophylaxis for hospitalized patients were published over a decade ago by the American Society of Health‐System Pharmacists [1] and based on current prescribing practices, appear to be either obsolete or ignored. According to a host of clinical studies, the benefit of acid suppressive therapy (AST), including P...

Objective: Chronic stress plays an important role in the etiology of many inflammatory diseases. Reactive oxygen species (ROS), a source free radicals, act as signaling molecules progression stress-related Oxidative occurs result increase radicals tissues. The damage caused by oxidative can be reduced antioxidant replacement. In our study, effect fulvic acid, powerful antioxidant, on water avoi...