Phosphoinositides are key lipids in eukaryotes, regulating organelles' identity and function. Their synthesis turnover require specific phosphorylation/dephosphorylation events that ensured by dedicated lipid kinases phosphatases, which modulate the structure of inositol ring adding or removing phosphates on positions 3, 4 5. Beside their implication intracellular signalization cytoskeleton dyn...

in this paper, a general solution for torsion of hollow cylinders made of functionally graded materials (fgm) was investigated. the problem was formulated in terms of prandtl’s stress and, in general, the shear stress and angle of twist were derived. variations in the material properties such as young’s modulus and poisson’s ratio might be arbitrary functions of the radial coordinate. various m...

Background: Dipentyl phthalate (DPeP) is a plasticizer compound commonly used in polyvinylchloride plastic to increase their softness and flexibility. They are not bound covalently to the plastic polymers and can therefore leach out into the environment, and have been shown to adversely affect the health of humans and animals. Methods: We investigated the effect of DPeP on the various cognitive...

we have studied the effect of amitriptyline, a tricyclic anti-depressant drug on several immune parameters of the balb/c mice in order to evaluate its immunomodulatory effects. results showed that amitriptyline will potentiates all of the immunocytes functions except for the production of pge2 by lps stimulated monocytes. we have also showed that amitriptyline can normalize the immunosuppressiv...