Chloroacetaldehyde (CAA) is a chlorination by-product in finished drinking water and a toxic metabolite of a wide variety of industrial chemicals (e.g. vinyl chloride) and chemotherapeutic agents (e.g. cyclophosphamide and ifosfamide). In this research, the cytotoxic mechanisms of CAA in freshly isolated rat hepatocytes were investigated.CAA cytotoxicity was associated with reactive oxygen spec...

Casing collapse is one of the major problems in oil fields, imposing a lot of costs on oil companies. This problem occurs not only at drilling times in some formations but also after the completion and production can lead to many problems. Analysis of the behavior of casing collapse in terms of geo-mechanics and solid mechanics could significantly meet the needs of the oil industry of Iran. In ...

BACKGROUND Kidney is known as the most sensitive target organ for depleted uranium (DU) toxicity in comparison to other organs. Although the oxidative stress and mitochondrial damage induced by DU has been well investigated, the precise mechanism of DU-induced nephrotoxicity has not been thoroughly recognized yet. METHODS Kidney mitochondria were obtained using differential centrifugation fro...

Chloroacetaldehyde (CAA) is a chlorination by-product in finished drinking water and a toxic metabolite of a wide variety of industrial chemicals (e.g. vinyl chloride) and chemotherapeutic agents (e.g. cyclophosphamide and ifosfamide). In this research, the cytotoxic mechanisms of CAA in freshly isolated rat hepatocytes were investigated.CAA cytotoxicity was associated with reactive oxygen spec...

Multi site damage is one of the important aspects to be studied to ensure the safety of the aircraft structure. The rivet hole locations are one of the stress concentration regions. The current study includes a panel which represents the fuselage splice joint. The fuselage splice joint is a location where it experiences the uniform stress field at many rivet locations in a row. This study has r...

Background: The mechanism of para-nonylphenol (PNP) reducing the proliferation and differentiation of bone marrow mesenchymal stem cells (MSCs) is not known. The present study was designed to investigate the mechanism. Methods: MSCs were extracted under sterile condition from Wistar rat and cultured in DMEM, containing 15 % FBS and penicillin/streptomycin until the 3rd passage, then cells we...

Expansive and collapsible soils are some of the most widely distributed and costly of geologic hazards. These soils are subject to changes in volume and settlement in response to wetting and drying, often resulting in severe damage to structures. Collapsing soils are generally characterized by sudden and large volume decrease at constant stress when inundated with water. A geotechnical engineer...

OBJECTIVES The current study examined whether the link between stress and health-related quality of life was buffered by protective factors, namely mindfulness, in a sample of middle-aged and older adults. METHODS In this cross-sectional study, 134 healthy, community-dwelling adults (ages 50-85 years) were recruited from Dallas, TX. The participants were screened for depressive symptoms and s...

In the current paper the results of a numerical simulation that were verified by a well instrumented experimental procedure for studying the arching effect over a trapdoor in sand is presented. To simulate this phenomenon with continuum mechanics, the experimental procedure is modeled in ABAQUS code using stress dependent hardening in elastic state and plastic strain dependent frictional harden...