Research has shown that conventional adaptive control and more sophisticated nonlinear approaches can suffer from a lack of robustness and transparency. In this paper, a multiple model technique is proposed that effectively incorporates established linear control methods within an inherently nonlinear framework. The resulting local model network (LMN) was found to describe the nonlinear dynamic...

Although clinical picture of amyotrophic lateral sclerosis (ALS) is a stereotypical one, resulting from combination of signs secondary to dysfunction of both upper motor neuron (UMN) and lower motor neuron (LMN), clinical heterogeneity is a consistent feature of the disease. Age of onset, relative mix of UMN and LMN signs, duration of the disease and association with other conditions are major ...

BACKGROUND In worms, as in other organisms, many tissue-specific promoters are sequestered at the nuclear periphery when repressed and shift inward when activated. It has remained unresolved, however, whether the association of facultative heterochromatin with the nuclear periphery, or its release, has functional relevance for cell or tissue integrity. RESULTS Using ablation of the unique lam...

The present work describes the methodology for predicting the behavior of extrapolation curves obtained in radionuclide standardization by 4pb-g coincidence measurements, applied to Na, developed at the Laboratório de Metrologia Nuclear of IPEN-CNEN/SP (LMN–Nuclear Metrology Laboratory). The LMN system consists of a proportional counter (PC) in 4p geometry coupled to a single or a pair of NaI(T...

Chronic equine laminitis causes persistent pain and lameness in affected animals and often necessitates euthanasia when pain management strategies become ineffective. Published studies as well as anecdotal reports suggest that this chronic inflammatory disease is associated with systemic alterations in immune responsiveness, perhaps involving an autoimmune component. We investigated this broad ...

During spatial navigation, the head orientation of an animal is encoded internally by neural persistent activity in the head-direction (HD) system. In computational models, such a bell-shaped "hill of activity" is commonly assumed to be generated by recurrent excitation in a continuous attractor network. Recent experimental evidence, however, indicates that HD signal in rodents originates in a ...

OBJECTIVE To determine clinically related characteristics in patients with pure lower motor neuron (LMN) syndromes, not fulfilling accepted diagnostic criteria, who were likely to respond to intravenous immunoglobulin (IVIg) treatment. METHODS Demographic, clinical, laboratory and neurophysiological characteristics were prospectively collected from patients with undifferentiated isolated LMN ...

Motor neuron disease (MND) is a progressive neurodegenerative condition, affecting pyramidal neurons of the corticospinal tract (upper motor neurons (UMN)), brainstem motor nerve nuclei and spinal cord anterior horn cells (lower motor neurons (LMN)). Clinical presentation varies, according to the site(s) affected and the relative balance between UMN and LMN signs (see Table 1). The term ‘amyotr...