Hợp chất flavone, tangeretin (1), và ba hợp steroid: ergosterol peroxide (2), sitoindoside I (3) stigmasterol (4) đã được phân lập từ thân rễ của cây thiên niên kiện lá lớn (Homalomena pendula). Cấu trúc hóa học chúng xác định dựa trên tích dữ liệu phổ cộng hưởng hạt nhân (1D 2D NMR) so sánh với các tài công bố. Các (1-3) lần đầu tiên chi Homalomena. Cao chiết n-hexane ethyl acetate này có hoạt...

The first investigation of the chemical constituents and bioactivities of Diospyros rubra Lec. is reported. D. rubra extracts were screened for antimicrobial, antimalarial and cytotoxic activities. They were only shown to be active antimalarials. The extracts with good antimalarial activity were isolated and extensively purified to give lupeol (1), lupenone (2), betulin (3), lupeol acetate (4),...

The successful preparation of extracts of the adrenal cortex which possessed the property of maintaining adrenalectomized animals (1, 2, 3) stimulated attempts to isolate the substance or substances responsible for this activity. Reichstein has pointed out in his review article (4) that, thus, far, several steroid compounds have been isolated from adrenal cortical extracts by Kendall, Reichstei...

Several phytosterols, stigmasterol, campesterol and ƒÀ-sitosterol, were shown to have potent anti-complementary activities. Stigmasterol was the most potent. A marked consumption of C4 was observed to have occurred when serum was incubated with these phytosterols, and ƒÀ-sitosterol and stigmasterol showed higher C4 consumption than campesterol. After the incubation of serum with these phytoster...

Stigmasterol, a kind of phytosterol, is present in small amounts in various foods. In the present study, we investigated the effects of stigmasterol on scopolamine-induced memory impairments using the passive avoidance and the Morris water maze tasks in mice. In addition, changes in memory-related molecules, including extracellular signal-regulated kinase (ERK) and cAMP response element-binding...

The chromatography fractionation of the hexane, chloroform and ethyl acetate extracts from the leaves and stems of Rourea doniana Baker, Connaraceae, resulted in the isolation of five triterpenes (lupeol, lupenone, α-amyrenone, β-amyrenone, and taraxerol), a flavonol (7,4’-dimethylkaempferol), a coumarin (scopoletin) and four phytosteroids (β-sitosterol, stigmasterol, β-sitosteryl-3-Oβ-D-glucop...

Peperomia pellucida (L.) Kunth has been studied as an anti-osteoporotic agent. However, there is no report about its estrogenic activity, which important for activity. Thus, the aim of this research was to study potency P. extracts. The activity extracts (n-hexane, ethyl acetate, ethanol, and water extracts) using E-screen assay confirmed with a molecular docking simulations. Further, presence ...

Cirsium arvense (L.) Scop., commonly known as creeping thistle, is a weed of Asteraceae. This study was undertaken to explore various phytoconstituents present in flower this weed. To achieve goal, the dried flowers were soaked methanol for one week and filtered. methanolic extract subjected GC-MS analysis 7 compounds identified. These included olean-12-en-3-ol, acetate, (3β)- (63.87%), lanosta...

Stigmasterol has been shown exhibit anti-osteoarthritic properties in vitro studies. However, the in vivo effects of stigmasterol on cartilage are still unclear. This study investigated the anti-osteoarthritic properties of stigmasterol on cartilage degradation in a rabbit model of osteoarthritis (OA). Twenty rabbits underwent bilateral anterior cruciate ligament transection (ACLT) to induce OA...

Extensive research has been carried out from last decades to discover potential constituents from plant sources. Stigmasterol is an important constituent and has been isolated from plants. It is involved in the synthesis of many hormones like progesterone, androgens, estrogens and corticoids. In addition to stigmasterol many of its derivatives like, spinasterol, fucosterol, cyasterone, stigmast...