The research presented in this thesis addresses the problem of updating an analytical model using a parametric Reference Basis approach. In this method, some parameters are assumed to be accurate (e.g. natural frequencies, mode shapes and mass matrix), while others are adjusted so that the eigenvalue equation is satisfied. Updating is done with the use of principal submatrices, and the method s...

Extracellular matrices determine cellular fate decisions through the regulation of intracellular force and stress. Previous studies suggest that matrix stiffness and ligand anchorage cause distinct signaling effects. We show herein how defined noncovalent anchorage of adhesion ligands to elastic substrates allows for dissection of intracellular adhesion signaling pathways related to matrix stif...

background: common carotid arterial stiffness can be assessed during carotid arterial ultrasonography, but its association with brachial stiffness, a well-defined cardiovascular risk factor, has not been clarified. the aim of this study was to examine the relationship between common carotid artery and brachial artery stiffness. methods: the static pressure-strain elastic modulus of the common c...

For the nonlinear analysis of structures using the well known Newton-Raphson Method, the tangent stiffness matrices of the elements must be constructed in each iteration. Due to the high expense required to find the exact tangent stiffness matrices, researchers have developed novel innovations into the Newton-Raphson method to reduce the cost and time required by the analysis. In this paper, a ...

First, the equations for calculating the full mass, stiffness and damping matrices from modal data are derived. This deviation was first presented in [1]. However, these equations are difficult to solve because the first step of their solution requires matrix inversion of the flexibility matrix to obtain the stiffness matrix. Not only does matrix inversion amplify errors, but the number of line...