Background: Rhodiola rosea L. originates from the plant family Crassulaceae and is known as an adaptogen increasing resistance to various stressors. The present study aimed to evaluate the effects of a commercially available standardized Rhodiola rosea L. extract administered intraperitoneally on cognitive processes in naive rats by using two passive avoidance tests. Methodology/Principal findi...

OBJECTIVES Auraptene (7-geranyloxycoumarin) (AUR), from Citrus species has shown anti-inflammatory, neuroprotective, and acetylcholinesterase (AChE) and beta-secretase inhibitory effects. Scopolamine is a nonselective muscarinic receptor antagonist which causes short-term memory impairments and is used for inducing animal model of Alzheimer's disease (AD). This research aimed to investigate the...

Some animal models have been used to study Alzheimer's disease (AD). AD is an irreversible progressive neurodegenerative disease and the most common cause of dementia. Animal studies have shown that there is a relation between decrease in cholinergic functions in the nucleus basalis of Meynert (NBM) and loss of learning capability and memory. The aim of this study was to investigate the effect ...

Some animal models have been used to study Alzheimer's disease (AD). AD is an irreversible progressive neurodegenerative disease and the most common cause of dementia. Animal studies have shown that there is a relation between decrease in cholinergic functions in the nucleus basalis of Meynert (NBM) and loss of learning capability and memory. The aim of this study was to investigate the effect ...

background: the spice zingiber officinale or ginger possesses antioxidant activity and neuroprotective effects. in this study we hypothesized that treatment with hydroethanolic extract of ginger (50, 100 and 200 mg/kg, p.o) would effect on the hyoscine-induced memory impairment in rats. methods: in this experimental study 64 male wistar rats were divided into eight groups (8 rats in each group)...

A B S T R A C T Introduction: Diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. Due to anti-diabetic and antioxidant activity of Rumex patientia (RP), this research study was conducted to evaluate the efficacy of chronic Rumex patientia feeding on alleviation of learning and memory disturbance in streptozo...

stress has a profound impact on the nervous system and causes cognitive problems that are partly related to the inflammatory effects. besides influencing the content of neurotransmitters, antidepressants such as doxepin are likely to have anti-inflammatory, anti-oxidative, and anti-apoptotic effects. therefore, the present study investigated the effects of doxepin on passive avoidance learning ...

Introduction: Similarities in the memory impairment between Alzheimer patients and scopolamine treated animals have been reported. In the present study, the possible role of α-adrenergic receptors of the dorsal hippocampus on scopolamine state-dependent memory in adult male Wistar rats was evaluated. Methods: The animals were bilaterally implanted with chronic cannulae in the CA1 regions o...