The effect of the hydrophobic group content in gelatin on the bonding strength of novel tissue-penetrating tissue adhesives was evaluated. The hydrophobic groups introduced into gelatin were the saturated hexanoyl, palmitoyl, and stearoyl groups, and the unsaturated oleoyl group. A collagen casing was employed as an adherend to model soft tissue for the in vitro determination of bonding strengt...

Our aim is to study the effects of varying the two acyl moieties in synthesized N,N-diacyl spermines on siRNA formulations and their delivery efficiency in cell lines. Six novel asymmetrical lipopolyamines: [N-cholesteryloxy-3-carbonyl-N-oleoyl-, N-decanoyl-N-oleoyl-, N-decanoyl-N-stearoyl-, N-lithocholoyl-N-oleoyl-, N-myristoleoyl-N-myristoyl-, and N­ oleoyl-N-stearoyl]-1,12-diamino-4,9-diazad...

Electrophilic attack of hypochlorous acid on unsaturated bonds of fatty acyl chains is known to result mostly in chlorinated products that show cytotoxicity to some cell lines and were found in biological systems exposed to HOCl. This study aimed to investigate more deeply the products and the mechanism underlying cytotoxicity of phospholipid-HOCl oxidation products, synthesized by the reaction...

Peroxisome proliferators induce stearoyl-CoA desaturase activity (EC 1.14.99.5) in liver [Kawashima, Y., Hanioka, N., Matsumura, M. & Kozuka, H. (1983) Biochim. Biophys. Acta 752, 259-264]. We analyzed the changes in stearoyl-CoA desaturase 1 (SCD1) mRNA to further define the molecular mechanism for the induction of stearoyl-CoA desaturase by peroxisome proliferators. SCD1 mRNA was analyzed fro...

Desaturation of [1-r4C]stearic acid, [lJ4C]palmitic acid, and [l-14C]stearoyl-CoA was measured in homogenates of lo-day-old rat brain. Desaturation was maximal with stearoyl-CoA at pH 6.0 to 6.6. With free fatty acids, monoene formation was maximal at pH 7.2 to 7.6; stearic acid was more actively desaturated than palmitic acid. Activity with stearic acid or stearoyl-CoA was linear with protein ...

Desaturation of [1-r4C]stearic acid, [lJ4C]palmitic acid, and [l-14C]stearoyl-CoA was measured in homogenates of lo-day-old rat brain. Desaturation was maximal with stearoyl-CoA at pH 6.0 to 6.6. With free fatty acids, monoene formation was maximal at pH 7.2 to 7.6; stearic acid was more actively desaturated than palmitic acid. Activity with stearic acid or stearoyl-CoA was linear with protein ...

s of plenary lectures, review sessions and orals sessions were originally published in OBESITY FACTS 4/2008 (S. Karger AG, Basel) ISBN 978-80-254-2733-0 THE ROLE OF STEAROYL-COA DESATURASE IN THE DEVELOPMENT OF HEPATIC STEATOSIS

Castor oil is the source of numerous products and is the only commercial source of the fatty acid ricinoleate, 12-hydroxy-oleate. Hydrogenated castor oil is similarly useful as the source of 12-hydroxy-stearic acid, best known as a component of lithium grease. Monoand diacylglycerols are derived from castor oil and are useful in development of lubricants and emulsifiers for cosmetics, pharmaceu...

Our aim is to study the effects of varying the two acyl moieties in synthesized N,N-diacyl spermines on siRNA formulations and their delivery efficiency in cell lines. Six novel asymmetrical lipopolyamines: [N-cholesteryloxy-3-carbonyl-N-oleoyl-, N-decanoyl-N-oleoyl-, N-decanoyl-N-stearoyl-, N-lithocholoyl-N-oleoyl-, N-myristoleoyl-N-myristoyl-, and N­ oleoyl-N-stearoyl]-1,12-diamino-4,9-diazad...