Line Associative Registers (LARs) are the basis for a new class of processor architectures in which memory accesses are minimized by explicitly managing wide lines of instructions and data in processor registers. The design of LARs has signi cant commonality with a number of existing technologies which have been more or less widely adopted, however, we rmly believe that LARs-based design, which...

Many regression problems exhibit a natural grouping among predictor variables. Examples are groups of dummy variables representing categorical variables, or present and lagged values of time series data. Since model selection in such cases typically aims for selecting groups of variables rather than individual covariates, an extension of the popular least angle regression (LARS) procedure to gr...

Several aminoacyl-tRNA synthetases have been reported to be overexpressed for charging essential aminoacyl-tRNAs in many cancer types. In this study, we aimed to explore the potential role of leucyl-tRNA synthetase (LARS) as an anticancer target. MTT assay was performed to screen inhibitors to human LARS (hsLARS) from compounds AN2690 and its derivatives, compounds 1-6, in U2OS and SKOV3 cells....

Most of this article concerns the uses of LARS and the two related methods in the age-old, " somewhat notorious, " problem of " [a]utomatic model-building algorithms.. . " for linear regression. In the following, I will confine my comments to this notorious problem and to the use of LARS and its relatives to solve it. 1. The implicit assumption. Suppose the response is y, and we collect the m p...

This article derives characterizations and computational algorithms for continuous general gradient descent trajectories in high-dimensional parameter spaces for statistical model selection, prediction, and classification. Examples include proportional gradient shrinkage as an extension of LASSO and LARS, threshold gradient descent with right-continuous variable selectors, threshold ridge regre...

Climate is a complex system which is changing mainly due to the increase of greenhouse gases. Because of the importance of climate change and the effects it can have on water resources, in recent years, this topic has been taken into consideration for different basins on Earth. The objective of this study is to investigate the effects of climate change and forecasting meteorological variables o...

Low anterior resection syndrome (LARS) is increasingly recognized as a concern after low anterior resection for the treatment of rectal cancer. The lack of a precise definition outlining the symptoms and the time course that constitute LARS hinders ongoing research into the incidence, risk factors, pathophysiology, and treatment of this syndrome. This review will outline the current characteriz...