We report the measurement of branching fractions and CP-violation asymmetries in B→ϕϕK decays based on a 711 fb−1 data sample containing 772×106 BB¯ events. The were recorded at ϒ(4S) resonance with Belle detector KEKB asymmetric-energy e+e− collider. For B+→ϕϕK+, fraction asymmetry measured below ηc threshold (mϕϕ<2.85 GeV/c2) are [3.43−0.46+0.48(stat)±0.22(syst)]×10−6 −0.02±0.11(stat)±0.01(sy...

interferons (ifns) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. although ifns have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. ifns exert their pleiotropic effects through their multisubunit cell surface recept...

BACKGROUND Podoplanin (PDPN)/T1α/aggrus/PA2.26 antigen, a transmembranous glycoprotein, is a well-known lymphatic endothelial marker. Recent evidence indicates that PDPN is also expressed in keratinocytes especially of sebaceous glands. OBJECTIVE To verify expression-pattern and the regulatory mechanism of PDPN in human epidermal keratinocytes. METHODS PDPN-expression pattern was analyzed i...

Background: Family holds an important role in the care of patient’s health against a disease or illness. The majority pulmonary TB (tuberculosis) patients have poor social support systems and compliance. Problems with impact on families family unpreparedness, lack knowledge about tuberculosis, discrimination (stigma) are some factors that need to be considered. resilience model improve complian...

Intragastric administration of soluble protein Ags results in peripheral tolerance to the fed Ag. To examine the role of cytokine regulation in the induction of oral tolerance, we fed OVA to mice deficient in Th1 (Stat 4-/-) and Th2 (Stat 6-/-) cells and compared their response to that of normal BALB/c controls. We found that, in spite of these deficiencies, OVA-specific peripheral cell-mediate...

We identified orthologues of all mammalian Janus kinase (JAK) and signal transducer and activator of transcription (STAT) genes in teleostean fishes, indicating that these protein families were already largely complete before the teleost tetrapod split, 450 million years ago. In mammals, the STAT repertoire consists of seven genes (STAT1, -2, -3, -4, -5a, -5b, and -6). Our phylogenetic analyses...

the aim of this study was to develop and obtain the reliability and validity of 8 items short form of spielberger stat-trait anxiety inventory (stai) for use in circumstances where the full form is inappropriate. in this study a correlational method is carried out. using the available sampling, the sample subjects were selected from 161 patients who referred to one of hospitals of isfahan. in t...

The transcription factor STAT-1 (signal transducer and activator of transcription-1) plays a pivotal role in the expression of inflammatory gene products involved in the pathogenesis of arthritis such as various cytokines and the CD40/CD40 ligand (CD40/CD40L) receptor-ligand dyad. The therapeutic efficacy of a synthetic decoy oligodeoxynucleotide (ODN) binding and neutralizing STAT-1 was tested...