نتایج جستجو برای: stat

تعداد نتایج: 11747  

Journal: :Journal of cell science 2005
Paul A Townsend Mark S Cragg Sean M Davidson James McCormick Sean Barry Kevin M Lawrence Richard A Knight Michael Hubank Phang-Lang Chen David S Latchman Anastasis Stephanou

STAT-1 plays a role in mediating stress responses to various stimuli and has also been implied to be a tumour suppressor. Here, we report that STAT-1-deficient cells have defects both in intra-S-phase and G2-M checkpoints in response to DNA damage. Interestingly, STAT-1-deficient cells showed reduced Chk2 phosphorylation on threonine 68 (Chk2(-T68)) following DNA damage, suggesting that STAT-1 ...

Journal: :The Journal of biological chemistry 2000
A Stephanou B K Brar T M Scarabelli A K Jonassen D M Yellon M S Marber R A Knight D S Latchman

We show here that exposure of cardiac cells to simulated ischemia results in apoptosis and is accompanied by phosphorylation and increased expression and transcriptional activity of STAT-1. Similarly, interferon-gamma, which is known to induce STAT-1 activation, also induced apoptosis in cardiac cells. STAT-1-transfected cells were more susceptible to ischemia-induced cell death than cells tran...

1998
Søren Skov Mette Nielsen Søren Bregenholt Niels Ødum Mogens H. Claesson

Activation of Janus tyrosine kinases (Jak) and Signal transducers and activators of transcription (Stat) after ligation of major histocompatibility complex class I (MHC-I) was explored in Jurkat T cells. Cross-linking of MHC-I mediated tyrosine phosphorylation of Tyk2, but not Jak1, Jak2, and Jak3. In addition, the transcription factor Stat-3 was tyrosine phosphorylated in the cytoplasma and su...

2014
LI-MIN CUI KUN ZHANG DONG-JIE MA SHUANG-PING LIU XUE-WU ZHANG

The aim of the present study was to investigate the expression of proteins associated with the sustained activation of the signal transducer and activator of transcription (STAT)-3 pathway during diethylnitrosamine (DEN)-induced rat liver carcinogenesis. DEN was intermittently administered to rats to induce liver cancer, and light and electron microscopy were used to observe the morphological c...

Journal: :Blood 1998
S Skov M Nielsen S Bregenholt N Odum M H Claesson

Activation of Janus tyrosine kinases (Jak) and Signal transducers and activators of transcription (Stat) after ligation of major histocompatibility complex class I (MHC-I) was explored in Jurkat T cells. Cross-linking of MHC-I mediated tyrosine phosphorylation of Tyk2, but not Jak1, Jak2, and Jak3. In addition, the transcription factor Stat-3 was tyrosine phosphorylated in the cytoplasm and sub...

2012
Vladislav V. Panov Julia L. Kuzmina Semen A. Doronin Marina R. Kopantseva Elena N. Nabirochkina Sofia G. Georgieva Nadezhda E. Vorobyeva Yulii V. Shidlovskii

Jak/STAT is an important signaling pathway mediating multiple events in development. We describe participation of metazoan co-activator SAYP/PHF10 in this pathway downstream of STAT. The latter, via its activation domain, interacts with the conserved core of SAYP. STAT is associated with the SAYP-containing co-activator complex BTFly and recruits BTFly onto genes. SAYP is necessary for stimulat...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1995
S Ruff-Jamison K Chen S Cohen

Intraperitoneal injection of epidermal growth factor into mice results in the appearance of multiple tyrosine-phosphorylated proteins in liver nuclei within minutes after administration. We have previously identified three of these proteins as Stat 1 alpha, Stat 1 beta (p91, p84), and Stat 3 (p89). In the present report we demonstrate that Stat 5 (p92), the recently described prolactin inducibl...

Journal: :Physical review letters 2006
D Acosta J Adelman T Affolder T Akimoto M G Albrow D Ambrose S Amerio D Amidei A Anastassov K Anikeev A Annovi J Antos M Aoki G Apollinari T Arisawa J-F Arguin A Artikov W Ashmanskas A Attal F Azfar P Azzi-Bacchetta N Bacchetta H Bachocou W Badgett A Barbaro-Galtieri G J Barker V E Barnes B A Barnett S Baroiant G Bauer F Bedeschi S Behari S Belforte G Bellettini J Bellinger A Belloni E Ben-Haim D Benjamin A Beretvas T Berry A Bhatti M Binkley D Bisello M Bishai R E Blair C Blocker K Bloom B Blumenfeld A Bocci A Bodek G Bolla A Bolshov D Bortoletto J Boudreau S Bourov B Brau C Bromberg E Brubaker J Budagov H S Budd K Burkett G Busetto P Bussey K L Byrum S Cabrera M Campanelli M Campbell F Canelli A Canepa M Casarsa D Carlsmith R Carosi S Carron M Cavalli-Sforza A Castro P Catastini D Cauz A Cerri L Cerrito J Chapman Y C Chen M Chertok G Chiarelli G Chlachidze F Chlebana I Cho K Cho D Chokheli J P Chou S Chuang K Chung W-H Chung Y S Chung M Cijliak C I Ciobanu M A Ciocci A G Clark D Clark M Coca A Connolly M Convery J Conway B Cooper K Copic M Cordelli G Cortiana J Cranshaw J Cuevas A Cruz R Culbertson C Currat D Cyr D Dagenhart S Da Ronco S D'Auria P de Barbaro S De Cecco A Deisher G De Lentdecker M Dell'Orso S Demers L Demortier M Deninno D Depedis P F Derwent C Dionisi J R Dittmann P DiTuro C Dörr A Dominguez S Donati M Donega J Donini M D'Onofrio T Dorigo K Ebina J Efron J Ehlers R Erbacher M Erdmann D Errede S Errede R Eusebi H-C Fang S Farrington I Fedorko W T Fedorko R G Feild M Feindt J P Fernandez R D Field G Flanagan L R Flores-Castillo A Foland S Forrester G W Foster M Franklin J C Freeman Y Fujii I Furic A Gajjar M Gallinaro J Galyardt M Garcia-Sciveres A F Garfinkel C Gay H Gerberich D W Gerdes E Gerchtein S Giagu P Giannetti A Gibson K Gibson C Ginsburg K Giolo M Giordani M Giunta G Giurgiu V Glagolev D Glenzinski M Gold N Goldschmidt D Goldstein J Goldstein G Gomez G Gomez-Ceballos M Goncharov O González I Gorelov A T Goshaw Y Gotra K Goulianos A Gresele M Griffiths C Grosso-Pilcher U Grundler J Guimaraes da Costa C Haber K Hahn S R Hahn E Halkiadakis A Hamilton B-Y Han R Handler F Happacher K Hara M Hare R F Harr R M Harris F Hartmann K Hatakeyama J Hauser C Hays H Hayward B Heinemann J Heinrich M Hennecke M Herndon C Hill D Hirschbuehl A Hocker K D Hoffman A Holloway S Hou M A Houlden B T Huffman Y Huang R E Hughes J Huston K Ikado J Incandela G Introzzi M Iori Y Ishizawa C Issever A Ivanov Y Iwata B Iyutin E James D Jang B Jayatilaka D Jeans H Jensen E J Jeon M Jones K K Joo S Y Jun T Junk T Kamon J Kang M Karagoz Unel P E Karchin Y Kato Y Kemp R Kephart U Kerzel V Khotilovich B Kilminster D H Kim H S Kim J E Kim M J Kim M S Kim S B Kim S H Kim Y K Kim M Kirby L Kirsch S Klimenko M Klute B Knuteson B R Ko H Kobayashi D J Kong K Kondo J Konigsberg K Kordas A Korn A Korytov A V Kotwal A Kovalev J Kraus I Kravchenko A Kreymer J Kroll M Kruse V Krutelyov S E Kuhlmann S Kwang A T Laasanen S Lai S Lami S Lammel M Lancaster R Lander K Lannon A Lath G Latino I Lazzizzera C Lecci T LeCompte J Lee S W Lee R Lefèvre N Leonardo S Leone S Levy J D Lewis K Li C Lin C S Lin M Lindgren E Lipeles T M Liss A Lister D O Litvintsev T Liu Y Liu N S Lockyer A Loginov M Loreti P Loverre R-S Lu D Lucchesi P Lujan P Lukens G Lungu L Lyons J Lys R Lysak E Lytken D MacQueen R Madrak K Maeshima P Maksimovic G Manca F Margaroli R Marginean C Marino A Martin M Martin V Martin M Martínez T Maruyama H Matsunaga M Mattson P Mazzanti K S McFarland D McGivern P M McIntyre P McNamara R McNulty A Mehta S Menzemer A Menzione P Merkel C Mesropian A Messina T Miao N Miladinovic J Miles L Miller R Miller J S Miller C Mills R Miquel S Miscetti G Mitselmakher A Miyamoto N Moggi B Mohr R Moore M Morello P A Movilla Fernandez J Muelmenstaedt A Mukherjee M Mulhearn T Muller R Mumford A Munar P Murat J Nachtman S Nahn I Nakano A Napier R Napora D Naumov V Necula J Nielsen T Nelson C Neu M S Neubauer T Nigmanov L Nodulman O Norniella T Ogawa S H Oh Y D Oh T Ohsugi T Okusawa R Oldeman R Orava W Orejudos K Osterberg C Pagliarone E Palencia R Paoletti V Papadimitriou A A Paramonov S Pashapour J Patrick G Pauletta M Paulini C Paus D Pellett A Penzo T J Phillips G Piacentino J Piedra K T Pitts C Plager L Pondrom G Pope X Portell O Poukhov N Pounder F Prakoshyn A Pronko J Proudfoot F Ptohos G Punzi J Rademacker M A Rahaman A Rakitine S Rappoccio F Ratnikov H Ray B Reisert V Rekovic P Renton M Rescigno F Rimondi K Rinnert L Ristori W J Robertson A Robson T Rodrigo S Rolli R Roser R Rossin C Rott J Russ V Rusu A Ruiz D Ryan H Saarikko S Sabik A Safonov R St Denis W K Sakumoto G Salamanna D Saltzberg C Sanchez L Santi S Sarkar K Sato P Savard A Savoy-Navarro P Schlabach E E Schmidt M P Schmidt M Schmitt T Schwarz L Scodellaro A L Scott A Scribano F Scuri A Sedov S Seidel Y Seiya A Semenov F Semeria L Sexton-Kennedy I Sfiligoi M D Shapiro T Shears P F Shepard D Sherman M Shimojima M Shochet Y Shon I Shreyber A Sidoti A Sill P Sinervo A Sisakyan J Sjolin A Skiba A J Slaughter K Sliwa

We measure the masses of b hadrons in exclusively reconstructed final states containing a J/psi --> mu-mu+ decay using 220 pb(-1) of data collected by the CDF II experiment. We find: m(B+) = 5279.10 +/- 0.41(stat.) +/- 0.36(sys.) MeV/c2, m(B0) = 5279.63 +/- 0.53(stat.) +/- 0.33(sys.) MeV/c2, m(B(s)0) = 5366.01 +/- 0.73(stat.) +/- 0.33(sys.) MeV/c2, m(lambda(b)0) = 5619.7 +/- 1.2(stat.) +/- 1.2(...

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