Pharmacodynamic effects and safety of single-dose inhaled loxapine administered via the Staccato(®) system and intramuscular (IM) lorazepam in combination versus each agent alone were compared in a randomized, double-blind, crossover study in healthy volunteers. Subjects received: inhaled loxapine 10 mg + IM lorazepam 1 mg; inhaled loxapine 10 mg + IM placebo; IM lorazepam 1 mg + Staccato place...

Many consider that Evolution and Creation are alternatives and therefore that one must make a choice between these two explanations of the natural world. This difficulty has dogged the debate since Darwin presented his explanation of the multiplicity and development of species in the 19th C. and even before. The issue has therefore become polarised and often the subject of bitter controversy. H...

Rules for legato, staccato, and repeated notes articulation in automatic piano performance are presented. These rules were obtained applying the analysis-by-measurement method to performances of Mozart piano sonatas on MIDIfied acoustic grand pianos. The effects produced by the rules vary with tempo indications, with expressive intentions and with musical context. The articulation rules are par...

BACKGROUND Despite the fact that functional lower urinary tract symptoms are common among people with Down syndrome (DS), their voiding function has not been studied precisely. Our goal was to assess the lower urinary tract functions in DS. METHODS Fifty-five DS children aged 5-15 years old and 35 age-matched control children were evaluated by ultrasonography and uroflowmetry. RESULTS Eleve...

This paper investigates the production and perception of different articulation techniques on the saxophone. In a production experiment, two melodies were recorded that required different effectors to play the tones (tongue-only actions, finger-only actions, combined tongue and finger actions) at three different tempi. A sensor saxophone reed was developed to monitor tongue-reed interactions du...

Enhanced statistical characterization of mood-rating data holds the potential to more precisely classify and sub-classify recurrent mood disorders like premenstrual dysphoric disorder (PMDD) and recurrent brief depressive disorder (RBD). We applied several complementary statistical methods to differentiate mood rating dynamics among women with PMDD, RBD, and normal controls (NC). We compared th...