Objective: Sterol regulatory element binding protein 1c (SREBP1c) is one of the major transcription factors that involved in nonalcoholicfatty liver disease (NAFLD) development by increasing hepatic fatty acid and triglyceride synthesis. Our study aimed toinvestigate interaction SREBP1c with endoplasmic reticulum (ER) stress oleic (OA) induced lipid accumulation.Material Methods: Optimum drople...

Obesity is reported to be associated with excessive growth of adipocyte mass tissue as a result of increases in the number and size of adipocytes differentiated from preadipocytes. To search for anti-adipogenic phytochemicals, we screened for inhibitory activities of various plant sources on adipocyte differentiation in 3T3-L1 preadipocytes. Among the sources, a methanolic extract of Salix pseu...

The lipid component of milk is an important energy source and a critical nutrient for proper development of the newborn. The lactating mouse secretes her entire body weight in fat during a normal lactation period. Fatty acids in milk triglyceride are blended from preformed sources (dietary and adipose stores), and de novo synthesized fatty acids. Factors that control lipogenic differentiation o...

Introduction: Orexin A and adiponectin are involved in controlling metabolism energy distribution the body during lactation. Lactation is a process with high demand for lipid synthesis. Peroxisome proliferator-activated receptor gamma (PPARγ) sterol regulatory element-binding protein 1 (SREBP1c) two transcription factors that regulate milk The goal of this study was to assess effects mammary ad...

Arginine methylation is responsible for diverse biological functions and is mediated by protein arginine methyltransferases (PRMTs). Nonalcoholic fatty liver disease (NAFLD) is accompanied by excessive hepatic lipogenesis via liver X receptor a (LXRa). Thus we examined the pathophysiological role of PRMTs in NAFLD and their relationship with LXRa. In this study, palmitic acid (PA) treatment inc...

BACKGROUND Non alcoholic fatty liver disease (NAFLD) results from alteration in lipid synthesis and elimination mechanisms such as very-low density lipoprotein (VLDL) production and de novo lipogenesis. Persistent organic pollutants (POPs) are chemicals that were mostly used historically as pesticides, solvents, flame retardant, and other applications. Among POPs, polychlorinated biphenyls (PCB...

BACKGROUND Food can modify the intestinal flora, and Lactobacillus ingluviei has been shown to cause weight gain in chicks and ducks but not in mammals. METHODOLOGY Female BALB/c mice were divided into a control and two experimental groups and were inoculated either once or twice with L. ingluviei or with PBS. Faecal samples were collected and tested using qPCR in order to detect and quantify...