Purpose To compare the sectoral structure-function relationships in glaucoma between two structural parameters, vessel density (VD) and thickness, in the peripapillary retinal nerve fiber layer (RNFL). Methods Optical coherence tomography (OCT) angiography (AngioVue/RTVue-XR) for VD and OCT (RS-3000) for peripapillary RNFL thickness were performed in 129 eyes from 129 subjects (94 glaucoma, 1...

The divalent cations Ca2+, Mg2+, Co2+, Mn2+, Sr2+, and Ba2+ were compared for their stimulatory or inhibitory effect on PG formation in rabbit kidney medulla slices. Calcium, manganese, and strontium ions stimulated PG generation up to 3- to 5-fold in a time- and dose-dependent manner (Ca2+ greater than Mn2+ approximately Sr2+) while the magnesium and cobalt ions were without significant effect...

Owing to similarity in both ionic size and polarity, strontium (Sr2+) is known to behave in a comparable way to calcium (Ca2+), and its role in bone metabolism has been well documented as both anti-resorptive and bone forming. In this study, novel quaternary strontium-doped phosphate-based glasses, containing 1, 3 and 5 mol% SrO, were synthesized and characterized. (31)P magic angle spinning (M...

The intracellular Ca2+ concentration of nearly all cells is kept at submicromolar levels. The magnitudes of transmembrane Ca2+ movement that maintain this steady state in the human red blood cell have long been debated. Although there is agreement that the physiologic extrusion of Ca2+ by the well-characterized Ca2+. ATPase amounts to 45 mumol/liter cells per h (1982. Nature (Lond.). 298:478-48...

The use of binomial analysis as a tool for determining the sites of action of neuromodulators may be complicated by the nonuniformity of release probability. One of the potential sources for nonuniformity of release probability is the presence of multiple forms of synaptotagmins, the Ca2+ sensors responsible for triggering vesicular exocytosis. In this study we have used Sr2+, an ion whose acti...

The removal of manganese and humic acid (HA) by two nanofiltration membranes, TFC-SR2 and TFC-SR3, was investigated in order to highlight the influence of speciation on manganese and HA retention. Manganese speciation and complexation with HA were modelled to understand how speciation could affect NF removal mechanisms. The behaviour of the two membranes was drastically different for manganese ...

Calcium (Ca2+), strontium (Sr2+), and barium (Ba2+) are expected to exert similar chemical and pharmacological effects. The effects of barium, strontium and calcium were studied on the contractions of rat phrenic nerve-diaphragm preparations, following electrical stimulation and their interactions with nifedipine (nif) and diltiazem (DZM) were also studied. Low doses of strontium chloride (SrCl...

Experiments were conducted in 10 isolated rabbit hearts at 25°C to test the hypothesis that vibration-induced depression of myocardial contractile function was the result of increased cross-bridge breakage. Small-amplitude sinusoidal changes in left ventricular volume were administered at frequencies of 25, 50, and 76.9 Hz. The resulting pressure response consisted of a depressive response [ΔPd...