Departamento de Bioquímica, Genética e Inmunología, Facultad de Biología, Universidad de Vigo, 36310 Vigo, Spain CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Porto, Campus Agrário de Vairão, 4485-661 Vairão, Portugal National Park Service, Yellowstone National Park, P.O. Box 168, WY 82190, USA d Liverpool School of Tropical Medicine, Pembroke Place, L3 5...

To the Editor—We read with interest the article by Neely et al [1], who reported their clinical pharmacokinetic and phar-macodynamic experience with voricona-zole in pediatric patients. The article raises interesting issues about the pharmacologic rationale for the approved oral dose of voriconazole in children. According to European recommendations , a fixed 200-mg oral dose should be given tw...

In the title compound, C(13)H(16)N(10)O(2)S·C(5)H(9)NO·H(2)O, the entire 1-methylpyrrolidin-2-one (NMP) mol-ecule is disordered over two sites with occupancies of 0.488 (5) and 0.512 (5). The six-membered triazine ring and the two five-membered pyrazole and thiadia-zole rings, together with the diazene (-N=N-) linkage are almost coplanar (r.m.s. deviation for the non-H atoms = 0.0256 Å) with me...

After injection of (45)Ca(++) or (89)Sr(++) into rats, the largest part of the radioactivity in the liver cell is associated with the subcellular structures, only negligible amounts of it being found in the soluble hyaloplasm. 50 % or more of the (45)Ca(++) and (89)Sr(++) in the liver cell is recovered in the mitochondrial fraction. The specific activity of Ca(++) after injection of (45)Ca(++) ...

Prostate cancer is a growing public health problem. The palliation of pain in patients with painful bone metastases is of primary importance in the clinical management of advanced cancer. Internal therapy with radionuclides, which concentrate at sites of increased bone turnover, is used to control pain and improve quality of life as an alternative to conventional therapies. In the present study...

BACKGROUND The Self-Report Wender-Reimherr Adult Attention Deficit Disorder Scale (SR-WRAADDS) assesses the same 7 attention-deficit/ hyperactivity disorder (ADHD) domains as the interviewer-administered WRAADDS. METHODS A normative sample was recruited, and additional participants came from trials involving ADHD, anxiety, or depression. Using the investigator-administered WRAADDS, participan...

Abstract The deconvolution of liquid scintillation (LS) spectra is meaningful in several scenarios like supporting incomplete radiochemical separations, for screening purposes and determining different isotopes the same element, which explored this paper case 89 Sr/ 90 Sr. In DECLAB , an online application analysis presented. software considers classical calibration modes constant efficiency qu...

This study aimed to compare the Social Representations (SR) of aging and quality life (QoL) in old age for riparian elderly. is a qualitative-exploratory with non-probabilistic sample. Sociodemographic questionnaires free word association technique were used. Participants 100 elderly, matched sex, aged 60-89 years (M = 70.08 years; SD 7.19). The IRaMuTeQ software was used through prototypical a...

AIMS To investigate the prevalence of awareness of the online illicit drug marketplace Silk Road (SR), consumption of drugs purchased from SR and reasons for use and non-use of SR. DESIGN AND SETTING Global Drug Survey: purposive sample collected in late 2012. PARTICIPANTS The base sample (n = 9470) reported recent drug purchase and resided in the United Kingdom (n = 4315, median age 24, 76...

The effects of in vivo modulation of HDL phospholipid (PL) on scavenger receptor class BI (SR-BI)- and ATP binding cassette transporter 1 (ABCA1)-mediated efflux were examined by overexpressing either endothelial lipase (EL) or phosphatidylserine phospholipase (PS-PLA1) in human apolipoprotein A-I (apoA-I) transgenic mice. Overexpression of EL led to large reductions in the serum PL/apoA-I rati...