Mechanical unfolding of several domains of calmodulin and titin is studied using a Go-like model with a realistic contact map and Lennard-Jones contact interactions. It is shown that this simple model captures the experimentally observed difference between the two proteins: titin is a spring that is tough and strong whereas calmodulin acts like a weak spring with featureless force-displacement ...

This report makes a case for the need to examine the methodological foundations of AI. Many aspects of AI have not yet developed to a point of general agreement. The goals of AI work, the methods for acheiving these goals, the presentation of results, and the assessment of claims are all highly contentious issues. All aspects of AI methodology are subject to debate The Workshop on the Foundatio...

Problem 1. Infinite Products and Coproducts in Ab. We have seen that finite products and coproducts agree in Ab. However, the same is not true for infinite products and coproducts. Let I be a set and let {Ai}i∈I be a family of abelian groups, each equal to some fixed group A. (a) Show that the set AI := HomSet(I, A) is an abelian group. Furthermore, show that we can think of this group as the i...

Abstract: It is difficult to weigh the light objects by weighing balance accurately when measured individually. If several light objects are weighed in groups rather than individually then the precision of the estimates increases quite considerably. There are two types of balances one is chemical balance and other is spring balance. Spring balance is similar when only one pan of chemical balanc...

We would like to welcome our readers to the twenty-eighth issue of 49 th Parallel and our second of 2012. In the last few months there have been some exciting developments at the journal and we hope that 49 th Parallel will continue to flourish in the future. We would like to welcome our new Articles Editor, Galateia Demetriou, to the 49 th Parallel team. Galateia is a second year doctoral rese...

THE RESPONSE of hitherto known practical forms of seismographs depends upon the relative motion of a pendulum and the moving ground to which ~ts supporting structure is fastened. The various kinds of seismographs differ in the type of pendulum used, such as gravity, spring, torsion, and/or they differ in the type of magnifying and recording elements which they employ. They all measure or indica...

Beijing’s mountainous areas have an important ecological significance because they are ecological conservation and water source protection areas of Beijing. The impact of precipitation on the vegetation coverage of Beijing’s mountainous areas is qualitatively analyzed using multi-temporal Landsat images obtained during the last 20 years. Firstly, the influence of external factors, such as pheno...