نتایج جستجو برای: spreading depression
تعداد نتایج: 168862 فیلتر نتایج به سال:
The characteristic form and development of sensory disturbances during migraine auras suggests that the underlying mechanism is a disturbance of the cerebral cortex, probably the cortical spreading depression (CSD) of Leio. The demonstration of unique changes of brain blood flow during attacks of migraine with aura, which have been replicated in animal experiments during CSD, constitutes anothe...
In a well-designed study, Piper et al. demonstrate that the induction of a cortical spreading depression (SD) by a stab wound to the cortex of the cat is dependent on the anesthetic employed. Isoflurane and halothane, commonly used volatile anesthetics in humans, inhibit SD. In contrast, a-chloralose, an injectable anesthetic, permits the induction of SD. The authors suggest that failure to obs...
Cortical spreading depression (CSD) is associated with severe hypoperfusion in mice. Using minimally invasive multimodal optical imaging, we show that severe flow reductions during and after spreading depression are associated with a steep decline in cerebral metabolic rate of oxygen. Concurrent severe hemoglobin desaturation suggests that the oxygen metabolism becomes at least in part supply l...
BACKGROUND AND PURPOSE Status epilepticus and cerebral ischemia stimulate persistent neurogenesis in the adult brain, but both conditions cause neuronal damage. We determined whether spreading depression, a common epiphenomenon of these conditions, stimulates persistent neurogenesis. METHODS We analyzed the effect of KCl-induced spreading depression on persistent neurogenesis and the spatio-t...
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