Spreading depression (SD) propagates in cortical regions that are different in their morphological and functional characteristics. We tested whether the propagation pattern of spreading depression was different between parts of the cortex. In six adult rats, we recorded the ECoG by a 4 x 4 electrode array that covered parts of the frontal, parietal cortex and the cingulate cortex. Simultaneousl...

Despite the lack of direct evidence, it is generally believed that top-down signals are mediated by the abundant feedback connections from higher- to lower-order sensory areas. Here we provide direct evidence for a top-down mechanism. We stained the visual cortex of the ferret with a voltage-sensitive dye and presented a short-duration contrast square. This elicited an initial feedforward and l...

s and Conference Presentations: Hartings JA, Okonkwo DO, Bullock MR, Shutter LA, Mathern B, Strong AJ. Spreading depolarizations and outcome after traumatic brain injury: a prospective observational study. Military Health System Research Symposium (8 Aug 2012; Ft. Lauderdale, FL). Hartings JA, Bullock MR, Zacko C, Vidgeon S, Ridder T, Stanger R, Fabricius M, Mathern B, Tolias C, Pahl C, Strong ...

Despite many efforts, the pathophysiology and mechanism of blast-induced traumatic brain injury (bTBI) have not yet been elucidated, partially due to the difficulty of real-time diagnosis and extremely complex factors determining the outcome. In this study, we topically applied a laser-induced shock wave (LISW) to the rat brain through the skull, for which real-time measurements of optical diff...