A method for producing polypeptide particles via in situ polymerization of N-carboxyanhydrides during spray-drying has been developed. This method was enabled by the development of a fast and robust synthetic pathway to polypeptides using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as an initiator for the ring-opening polymerization of N-carboxyanhydrides. The polymerizations finished within 5 s a...

Spray drying is a common drying technique in food industries to convert liquid to powder form. A good understanding on the dynamic behavior of the process is important to ensure proper control. The aim of this study is to develop empirical models for spray drying of whole milk powder and orange juice powder. A preliminary study on the effect of several inputs such as inlet air temperature, feed...

A new type of spray dryer was developed for drying milk and the like efficiently. To this end, freely rotatable propellers powered with air-flow were placed in chamber to increase thermal efficiency product yield newly dryer. Milk samples dried both system a standard compare efficiencies yields each. It observed that had caused change flow direction air, decreased temperature walls, increased d...

This paper presents the prediction of air flow, humidity and temperature patterns in a co-current pilot plant spray dryer fitted with a pressure nozzle using a three dimensional model. The modelling was done with a Computational Fluid Dynamic package (Fluent 6.3), in which the gas phase is modelled as continuum using the Euler approach and the droplet/ particle phase is modelled by the Discrete...

In present study, spray-dried sourdough was produced using a pilot scale spray dryer and the physico-chemical and microbial characteristics of the obtained sourdough powder were investigated. The application of the spray-dried sourdough at different levels (3%, 6%, 9% and 15%) in breadmaking was also evaluated. Bulk density, wettability and suspensibility of the sourdough powder were 0.6 g/cm(3...

Hesperidin nanocrystals was generated by high pressure homogenization. The physicochemical properties of a spray dried hesperidin nanocrystals were investigated including to re-dispersion, crystalline state, kinetic solubility, dissolution velocity. Hesperidin nanosuspension with concentration of 10% (w/v) was dried by a Mini Spray-dryer B-190. Photon correlation spectroscopy (PCS) and laser di...

This paper is concerned with the numerical simulation of gas flow inside spray dryers, which is known to be highly transient. Experimental evidence presented in the literature to date is acquired either at a scale much smaller than industrial or at a limited number of locations in the system (e.g. the central axis). Alternatively, computational fluid dynamics (CFD) simulation, in particular met...

Microspheres containing yttrium (Y) and/or phosphorus (P) around 25 μm are useful for radioembolization therapy because they are activated to β-emitter by neutron bombardment and infused in blood vessels in the neighborhood of tumors to irradiate β-rays to the tumors. In this study, we attempt to prepare Y and P-containing microspheres by spray drying method. Starting solution containing yttriu...

Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer's disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug, Rivastigmine, in combination with the natural polymer, chitosan, for transdermal drug delivery applications. The content of the drug was determined ...