Three new amphiphilic molecules were synthetized on a basis of common monomer, octadecyl succinic anhydride (OSA), which grafted different PEGylated hydrophilic polar head. The objective this study is to investigate potential relationship between the chemical structure surfactant, and efficiency generate nano-emulsions through spontaneous nano-emulsification method. Beyond innovative synthesis ...

AIM The complications of intraocular silicone oil include emulsification, which may lead to vision-threatening disorders such as keratopathy, secondary glaucoma and retinopathy. The authors study the effect of mechanical energy from surgical instruments on the emulsification of silicone oil. METHODS Three different handpieces (phacofragmentation, phacoemulsification, high-speed vitrectomy) we...

Poor water solubility remains main culprit for the formulation scientist which can be overcome by nanonization. Nanoemulsion is kinetically stable and isotropic system of two immiscible liquids in sub microne size range. Nanoemulsions are composed of oil droplets dispersed in an aqueous medium and stabilized by surfactant molecules. Advantages of nanoemulsions include increased drug loading and...

Spontaneous emulsification through microchannels, in which droplets are formed due to Laplace pressure difference, is a relatively new technique for preparing monodisperse emulsions. The technique is extremely suited for products containing temperature and shear sensitive ingredients and for products that require high monodispersity; however, industrial application is still not possible due to ...

Chitosan was modified by coupling with linoleic acid through the 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide-mediated reaction to increase its amphipathicity for improved emulsification. The micelle formation of linoleic acid-modified chitosan in the 0.1 M acetic acid solution was enhanced by O/W emulsification with methylene chloride, an oil phase. The fluorescence spectra indicate that with...