Phased haplotype sequences are a key component in many population genetic analyses since variation in haplotypes reflects the action of recombination, selection, and changes in population size. In humans, haplotypes are typically estimated from unphased sequence or genotyping data using statistical models applied to large reference panels. To assess the importance of correct haplotype phase on ...

A new coronavirus, MERS-CoV (Middle East Respiratory Syndrome-Coronavirus) which is related to the coronavirus that caused the SARS outbreak 10 years ago, has been discovered in Saudi Arabia and observed in several other countries since 2012. A mathematical model is constructed in order to theorize possible patterns of the spread of this emerging disease which seems to require an extended conta...

1 Global Health Academy and Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom, 2 Croatian Centre for Global Health, Faculty of Medicine, University of Split, Soltanska, Split, Croatia, 3 Department of Health, Aging and Society, McMaster University, Hamilton, Ontario, Canada, 4 Department of Psychology, Stellenbosch University,...

Question: How is the process of evolutionary branching influenced by demographic stochasticity? Mathematical methods: Adaptive dynamics of (i) a simple consumer-resource model and (ii) an analogous but individual-based model with finite population size. Key assumptions: Consumers have access to two habitats with dynamic resources. The fraction of time spent in each habitat is the evolving trait...

We conducted an extensive set of empirical analyses to examine the effect of the number of events per variable (EPV) on the relative performance of three different methods for assessing the predictive accuracy of a logistic regression model: apparent performance in the analysis sample, split-sample validation, and optimism correction using bootstrap methods. Using a single dataset of patients h...