During Drosophila development Suppressor of Hairless [Su(H)]-dependent Notch activation upregulates transcription of the Enhancer of split-Complex [E(spl)-C] genes. Drosophila melanogaster E(spl) genes share common transcription regulators including binding sites for Su(H), proneural, and E(spl) basic-helix-loop-helix (bHLH) proteins. However, the expression patterns of E(spl) genes during deve...

Spinophilin (SPL) and neurabin (NRB) are structurally similar scaffolding proteins with several protein binding modules, including actin and PP1 binding motifs and PDZ and coiled-coil domains. SPL also binds regulators of G protein signaling (RGS) proteins and the third intracellular loop (3iL) of G protein-coupled receptors (GPCRs) to reduce the intensity of Ca(2+) signaling by GPCRs. The role...

Methylmercury (MeHg) is a ubiquitous environmental contaminant and neurotoxicant that has long been known to cause a variety of motor deficits. These motor deficits have primarily been attributed to MeHg targeting of developing neurons and induction of oxidative stress and calcium dysregulation. Few studies have looked at how MeHg may be affecting fundamental signaling mechanisms in development...

The Penman text generation system has been used within several different experimental application domains, demonstrating that it provides the basis for an adaptable general purpose text generation capability. Linking with these applications also indicated several ways that Penman's interface with applications could be improved. Penman's interface with applications is described, focusing on SPL,...

Software Product Line (SPL) Engineering has proved to be an effective method for software production. However, in the SPL community it is well recognized that variability in SPLs is increasing by the thousands. Hence, an automatic support is needed to deal with variability in SPL. Most of the current proposals for automatic reasoning on SPL are not devised to cope with extra– functional feature...

An interesting device design including a zirconium oxide (ZrO 2 ) current blocking layer (CBL) and ZrO surface passivation (SPL) is employed to manufacture GaN/InGaN light-emitting diode (LED). Based on the inherently good performance of , spreading effect undesired leakage are efficiently enhanced suppressed, respectively. Energy-dispersive X-ray spectroscopy (EDS), atomic force microscopy (AF...

background in many industries, noise is attributed as the most prevalent harmful agent threatening workers' health. geographic information system (gis) is an applicable surveying tool in civil engineering. but, the use of gis for noise and hearing loss screening seems to be partly a new approach. objectives this study aimed to apply gis in noise and hearing loss screening in the production hall...

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that promotes cardiomyocyte survival and contributes to ischemic preconditioning. S1P lyase (SPL) is a stress-activated enzyme responsible for irreversible S1P catabolism. We hypothesized that SPL contributes to oxidative stress by depleting S1P pools available for cardioprotective signaling. Accordingly, we evaluated SPL inhibition as a...

Sphingolipid metabolites such as sphingosine-1-phosphate (S1P) and ceramide modulate apoptosis during development and in response to stress. In general, ceramide promotes apoptosis, whereas S1P stimulates cell proliferation and protects against apoptosis. S1P is irreversibly degraded by the enzyme S1P lyase (SPL). In this study, we show a crucial role for SPL in mediating cellular responses to ...