OBJECTIVE Quantified risks of congenital Toxoplasma gondii infection and abnormal pregnancy outcomes following primary maternal infection were evaluated with meta- analysis based on published studies. METHODS The related literatures were searched in multiple literature databases regardless of languages. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the risks of vertic...

BACKGROUND Control programs have been executed in an attempt to reduce vertical transmission and the severity of congenital infection in regions with a high incidence of toxoplasmosis in pregnant women. We aimed to evaluate whether treatment of pregnant women with spiramycin associated with a lack of monitoring for toxoplasmosis seroconversion affects the prognosis of patients. METHODS We per...

Four macrolide-resistant Arcanobacterium pyogenes isolates contained A2058T, A2058G, or C2611G (Escherichia coli numbering) mutations in their 23S rRNA genes. While these mutations conferred resistance to erythromycin, oleandomycin, and spiramycin, they did not confer resistance to tylosin.

Background: Acne vulgaris is a self-limited disease that mainly involves the sebaceous follicles. Systemic antibiotic is a common therapeutic modality, so bacterial resistance can be a problem. Objectives: Assessment of Propionibacterium resistance to erythromycin, tetracycline, clindamycin and spiramycin. Patients and Methods: Sampling was done on lesions of 123 patients with acne vulgaris who...

The in vitro activities of enrofloxacin, florfenicol, oxytetracycline and spiramycin were determined against field isolates of Mycoplasma mycoides mycoides large colony (MmmLC) by means of the broth microdilution technique. The minimum inhibitory concentrations (MICs) of these antimicrobial drugs were determined for a representative number of 10 isolates and 1 type strain. The susceptibility of...

BACKGROUND The different laboratory methods used in the diagnosis of congenital toxoplasmosis have variable sensitivity and specificity. There is no evidence to prove that maternal treatment reduces the risk of fetal infection. The purpose of this study was to assess methods for the confirmation of congenital toxoplasmosis after maternal treatment with spiramycin during pregnancy, and to evalua...

Nineteen mycophenolic acid (MPA) derivatives were designed and synthesized, their anti-Toxoplasma activity evaluated for the first time. Among them, N-propylimidazole-modified compound E5 demonstrated strongest activity, IC50 against HFF-1 (Human Foreskin Fibroblasts-1) cells following infection with T. gondii is 80.9 μM (MPA-211.5 μM) its selectivity index 2.2 (MPA-1.2). In vivo experiments, c...

During recent months, trials have been undertaken with three relatively new substances in the treatment of non-gonococcal urethritis in males. Two of these, novobiocin and spiramycin, are antibiotics. Novobiocin (also known as Streptonivicin, Albamycin, Cathomycin, Cathocin) has been prepared from the Streptomyces niveus and from Streptomyces spheroides and was developed in the United States. A...

BACKGROUND Hypersensitivity reactions to metronidazole are infrequently described. However, we believe that such reactions are increasing due to growing use of the drug for the treatment of amebiasis and anaerobe infections combined with other antibiotics. The present study assesses the need for oral provocation in patients with probable hypersensitivity reactions to metronidazole. METHODS We...