In this study, the efficacy of pyriproxyfen and spinosad, alone and in combination, was evaluated against the dengue vector Aedes aegypti (L.). Larval bioassays were carried out on susceptible mosquito larvae to determine the concentration-mortality responses of mosquitoes exposed to each insecticide alone and in mixture. Synergism between pyriproxyfen and spinosad was determined by the calcula...

Neurological side effects consistent with ivermectin toxicity have been observed in dogs when high doses of the common heartworm prevention agent ivermectin are coadministered with spinosad, an oral flea prevention agent. Based on numerous reports implicating the role of the ATP-binding cassette drug transporter P-glycoprotein (P-gp) in ivermectin efflux in dogs, an in vivo study was conducted ...

In the study reported here, the pioneer fipronil/(S)-methoprene topical product (Frontline® Plus, Merial Limited, Duluth, GA) was compared to the oral spinosad product (Comfortis® Elanco, Greenfield, IN) for efficacy against adult fleas and preventing egg production. The product presentations, doses and labelling were the one applicable in the USA. Using a standard protocol, 200 cat fleas of mi...

The potential for using spinosad to protect Australian grain from storage insects is discussed. Spinosad is produced from the metabolic by-products of a soil-dwelling bacterium, and is active against a range of insect species. Studies on relevant susceptible and resistant strains of a range of beetle and psocid pests indicate that spinosad efficacy varies greatly between species. Among the five...

Spinosad is a natural insecticide with desirable qualities, and it is widely used as an alternative to organophosphates for control of pests such as the melon fly, Bactrocera cucurbitae (Coquillett). To monitor the potential for development of resistance, information about the current levels of tolerance to spinosad in melon fly populations were established in this study. Spinosad tolerance bio...

Susceptibility to spinosad (Success®/Tracer®) of beet armyworm (Spodoptera exigua) from the southern U.S.A. and Southeast Asia was determined through exposure of third instar larvae to dipped cotton leaves. LC50 values of field populations ranged from 0.6 to 14 μg spinosad/ml. Field populations were 3.0 to 70-fold less susceptible to spinosad than was a susceptible reference population. The lea...

Spinosad is a relatively new insecticide that exerts its toxic action via nicotinic acetylcholine receptors (nAChRs). Spinosad resistance in house flies appears to be due to an altered target site. To evaluate the molecular basis of spinosad resistance, two nAChR subunit genes, Mdα5 and Mdβ3 were cloned and characterized from an insecticide-susceptible (aabys) and spinosad resistant (rspin) str...

materials and methods statistical and regressive modeling methods were used to investigate the effects of the carbon source and to optimize the production media. results the spinosad production of s. spinosa co121 increased 77.13%, from 310.44 ± 21.84 μg/ml in the initial fermentation medium (with glucose as the main carbon source) to 549.89 ± 38.59 μg/ml in a new optimized fermentation medium ...

We identified spinosad-resistant populations of Frankliniella intonsa (Trybom) in strawberry greenhouses Nara city and Kashiba city. The mortality rate the population for spinosad commercial concentration was 6.5%, but that 86.2%. This suggested F. collected from Prefecture developed resistance to spinosad.

In 2005 the United States Environmental Protection Agency registered spinosad as a grain protectant at 1 μg(AI)/g. The effectiveness of spinosad at 1 μg(AI)/g against many beetle and moth pests of stored grains is well established. In recent years, several psocid species have emerged as economically important pests in various stored-product environments in many countries, including the United S...