BACKGROUND Spindle cell tumors of the larynx are rare. In some cases, the dignity is difficult to determine. We report two cases of laryngeal spindle cell tumors. CASE PRESENTATION Case 1 is a spindle cell carcinoma (SPC) in a 55 year-old male patient and case 2 an inflammatory myofibroblastic tumor (IMT) in a 34 year-old female patient. A comprehensive morphological and immunohistochemical a...

Spindle cell rhabdomyosarcoma is a rare subtype of rhabdomyosarcoma mainly seen in children. Occasional aberrant staining with a variety of immunohistochemical markers has been noted. The aberrantly expressed markers include alpha-smooth muscle actin, cytokeratin, S100, neurofilaments, CD20, immunoglobins, and CD117. We report herein two pediatric cases displaying strong CD34 positivity and one...

The diagnosis of cutaneous and subcutaneous spindle cell neoplasms in children is often challenging has potential therapeutic prognostic implications. Although correctly diagnosing dermatofibrosarcoma protuberans infantile fibrosarcoma paramount, pathologists should not ignore a number diagnostic pitfalls linked to mostly rare tumors with completely different clinical outcomes. In the last deca...

Kaposi's sarcoma (KS) is a highly vascularized tumor supporting large amounts of neo-angiogenesis. The major cell type in KS tumors is the spindle cell, a cell that expresses markers of lymphatic endothelium. KSHV, the etiologic agent of KS, is found in the spindle cells of all KS tumors. Considering the extreme extent of angiogenesis in KS tumors at all stages it has been proposed that KSHV di...

Human intraocular tumors and tumors derived from human tumor cell lines grown subcutaneously in the athymic nude mouse were scanned by diagnostic ultrasound. Radiofrequency scan data were converted to digital form and analyzed in the frequency domain. Characteristics of normalized power spectra were found to be significantly different among human spindle cell malignant melanomas, mixed/epitheli...

BACKGROUND The histologic diagnosis of atypical fibroxanthoma (AFX) can sometimes be challenging. No specific marker exists to confirm the diagnosis other than excluding other entities. CD163 has been shown to have great specificity for tumors of monocyte/histiocyte lineage. In this study, we evaluated the diagnostic utility of CD163 in diagnosing AFX and in identifying skin lesions with histio...

Most primary bladder tumors in children are predominantly malignant mesenchymal tumors, usually rhabdomyosarcoma. Several uncommon non-urothelial bladder tumors have been described and must be differentiated from sarcomatoid carcinoma. These include postoperative spindle cell nodule, inflammatory myofibroblastic tumor, leiomyoma, hemangioma and neurofibromas. IMT usually affects adolescents. Th...

Spindle cell lipomas (SCL) are benign, slow growing tumors arising most frequently in the subcutaneous tissue of the upper back, posterior neck, and shoulders in males aged 40-70 years. Local excision is generally curative. Classification of lipomatous tumors has progressed recently, and tumors of similar morphology and unusual presentation are increasingly reported, thereby making correct diag...

Spindle cell carcinomas are biphasic tumors of monoclonal origin with mesenchymal component proved to be the dedifferentiated forms of conventional squamous cell carcinomas. This unusual variant of squamous cell carcinoma usually presents in the larynx, but are also infrequently reported in the gingiva, tongue, lips, hypopharynx and nasal cavity. We report a spindle cell carcinoma of buccal muc...