a spinal cord injury (sci) refers to any injury to the spinal cord or nerves at the end of the spinal canal that is caused by trauma instead of disease often causes permanent changes in strength, sensation and other body functions below the site of the injury. road traffic collision (rtc) or car crash occurs when a vehicle collides with another vehicle, pedestrian, animal, road debris, or other...

background & aim: patients with spinal cord injury (sci) impose a heavy burden on health care system. awareness on prevalence and incidence of sci is important because this would show the necessity of prevention. this study aimed to investigate the epidemiology and types of traumatic spinal cord injuries in a trauma referral center in guilan. methods & materials/patients: this is a descriptive ...

BACKGROUND Spinal injury in children is rare, and poses many difficulties in management. AIMS To ascertain the prevalence of spinal injury within the paediatric trauma population, and to assess relative risks of spinal injury according to age, conscious level, injury severity score (ISS), and associated injuries. METHODS Spine injured children were identified from the UK Trauma Audit & Rese...

Neuroprotective agents such as methylprednisolone and sildenafil may limit damage after spinal cord injury. We evaluated the effects of methylprednisolone and sildenafil on biochemical and histologic changes after spinal cord injury in a rabbit model. Female New Zealand rabbits (32 rabbits) were allocated to 4 equal groups: laminectomy only (sham control) or laminectomy and spinal trauma with n...

OBJECTIVES AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models. The aim of this study was to evaluate the effect of AMPK/SIRT1 pathway on autophagy after spinal cord injury (SCI). MATERIALS AND METHODS The SCI model was established in rats in vivo and the primary spinal cord neurons were subjecte...

Spinal fractures represent 3% to 6% of all skeletal injuries. Spine trauma is a complex diagnostic area in which the radiological assessment is crucial. Plain radiography is often used as the initial diagnostic modality. However, stabilization of the acutely injured spine is a primary concern. In this respect, computed tomography (CT) is vastly superior to plain film in terms of speed and accur...

Study Design Systematic review. Objective We assessed the current state of spine registries by collecting spine trauma data and assessing their compliance to defined registry standards of being clinical quality. We ascertained if these registries collected spinal cord injury data alone or with spine column trauma data. Methods A systematic review was performed using MEDLINE and Embase databases...

Primary damage to the blood-spinal cord barrier (BSCB) is a nearly universal consequence of spinal cord injury that contributes significantly to the overall pathology. We have characterized quantitatively the extent and severity of primary, physical disruption of the BSCB in adult rats five minutes and fifteen minutes after graded trauma induced with the Impactor weight drop model of spinal cor...

Bone loss after spinal cord injury leads to increased fragility of bone and subsequent risk for low-trauma fractures in the sublesional parts of the body. Although in such injuries upper limbs are normally innervated, bone loss may occur in the upper extremities. The present study was designed to determine the systemic effects of spinal cord injury on the fracture healing of upper limbs in rabb...