نتایج جستجو برای: sphingosine kinase 1 phosphate

تعداد نتایج: 2966039  

Journal: :International Journal of Molecular Sciences 2021

Sphingosine kinase-1 (Sphk1) and its product, sphingosine-1-phosphate (S1P) are important regulators of cardiac growth function. Numerous studies have reported that Sphk1/S1P signaling is essential for embryonic development promotes pathological hypertrophy in adulthood. However, no addressed the role Sphk1 postnatal cardiomyocyte (CM) so far. The present study aimed to assess molecular mechani...

Journal: :The Journal of Cell Biology 1993
N N Desai R O Carlson M E Mattie A Olivera N E Buckley T Seki G Brooker S Spiegel

Sphingosylphosphorylcholine (SPC), or lysophingomyelin, a wide-spectrum growth promoting agent for a variety of cell types (Desai, N. N., and S. Spiegel. 1991. Biochem. Biophys. Res. Comm. 181: 361-366), stimulates cellular proliferation of quiescent Swiss 3T3 fibroblasts to a greater extent than other known growth factors or than the structurally related molecules, sphingosine and sphingosine-...

2013
Huan Yu Xiangxin Che Xiaoyuan Xu Meirong Zheng Yong Zhao Wei He Jingmou Yu Jianjun Xiong Weidong Li

OBJECTIVE Experimental and clinical studies have shown that administration of insulin during reperfusion is cardioprotective, but the mechanisms underlying this effect are still unknown. In this study, the ability of insulin to protect apoptotic cardiomyocytes from hypoxia/reoxygenation injury using the sphingosine kinase/sphingosine 1-phosphate axis was investigated. METHODS AND RESULTS Rat ...

Journal: :The Journal of biological chemistry 1992
B M Buehrer R M Bell

Sphingosine kinase was partially purified and characterized from rat brain microsomes. A new assay, utilizing octyl-beta-D-glucopyranoside and sphingosine mixed micelles, was developed to quantitate formation of the sphingosine-1-phosphate product. The assay was proportional with respect to time and protein, displayed Michaelis-Menten kinetics, and was subject to surface dilution in regard to t...

Journal: :Analytical chemistry 2008
Katherine J Lee Simon M Mwongela Sumith Kottegoda Laura Borland Allison R Nelson Christopher E Sims Nancy L Allbritton

Regulation of sphingosine and sphingosine-1-phosphate concentrations is of growing interest due to their importance in cellular signal transduction. Furthermore, new pharmaceutical agents moderating the intracellular and extracellular levels of sphingosine metabolites are showing promise in preclinical and clinical trials. In the present work, a quantitative assay relying on capillary electroph...

Journal: :Cell reports 2016
Megan M Young Yoshinori Takahashi Todd E Fox Jong K Yun Mark Kester Hong-Gang Wang

Sphingosine kinase 1 (Sphk1) associates with early endocytic membranes during endocytosis; however, the role of sphingosine or sphingosine-1-phosphate as the critical metabolite in endocytic trafficking has not been established. Here, we demonstrate that the recruitment of Sphk1 to sphingosine-enriched endocytic vesicles and the generation of sphingosine-1-phosphate facilitate membrane traffick...

Journal: :Indian Journal of Pharmaceutical Sciences 2022

To investigate the effects and mechanism of sphingosine-1-phosphate/sphingosine-1-phosphate receptor on pro-angiogenesis in human colon cancer cells is main objective. The sphingosine-1-phosphate HT-29 SW480 were assessed by tube formation assay. Quantitative real-time polymerase chain reaction was used to detect expression interleukin-8, interleukin-6 vascular endothelial growth factor HT29 af...

Journal: :Cancer research 2000
V E Nava O Cuvillier L C Edsall K Kimura S Milstien E P Gelmann S Spiegel

Ceramide has been implicated as an important component of radiation-induced apoptosis of human prostate cancer cells. We examined the role of the sphingolipid metabolites--ceramide, sphingosine, and sphingosine-1-phosphate--in susceptibility to radiation-induced apoptosis in prostate cancer cell lines with different sensitivities to gamma-irradiation. Exposure of radiation-sensitive TSU-Pr1 cel...

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