نتایج جستجو برای: sphingosine 1 phosphate
تعداد نتایج: 2821340 فیلتر نتایج به سال:
Psoriasis is a long-lasting skin condition characterized by redness and thick silver scales on the skin’s surface. It involves various cells, including keratinocytes, dendritic T lymphocytes, neutrophils. The treatments for psoriasis range from topical to systemic therapies, but they only alleviate symptoms do not provide fundamental cure. Moreover, have disadvantage of suppressing entire body’...
Alveolar macrophages from chronic obstructive pulmonary disease patients and cigarette smokers are deficient in their ability to phagocytose apoptotic bronchial epithelial cells (efferocytosis). We hypothesized that the defect is mediated via inhibition of sphingosine kinases and/or their subcellular mislocalization in response to cigarette smoke and can be normalized with exogenous sphingosine...
Dihydrosphingosine, an intermediate in the de novo synthesis of ceramide, induced proliferation of Swiss 3T3 cells. The proliferative effects of this lipid were much more potent than those of sphingosine, a break-down product of ceramide. The maximal proliferative response to dihydrosphingosine occurred at relatively low concentrations (1 microM), while sphingosine produced its maximal effect a...
This paper explores the way ceramide, sphingosine, ceramide 1-phosphate, and sphingosine 1-phosphate modulate the generation of second lipid messengers from phosphatidic acid in two experimental models of the central nervous system: in vertebrate rod outer segments prepared from dark-adapted retinas as well as in rod outer segments prepared from light-adapted retinas and in rat cerebral cortex ...
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