نتایج جستجو برای: spermatogenesis impairment
تعداد نتایج: 143324 فیلتر نتایج به سال:
The azoospermia factor c (AZFc) region in the long arm of human Y chromosome is characterized by massive palindromes. It harbors eight multi-copy gene families that are expressed exclusively or predominantly in testis. To assess systematically the role of the AZFc region and these eight gene families in spermatogenesis, we conducted a comprehensive molecular analysis (including Y chromosome hap...
dear editor, the problem of congenital hemoglobin disorder is common in tropical asia. in tropical southeast asian countries, very high prevalence of thalassemia disorder especially for beta thalassemia is observed. this tropical hematological problem affects millions of population and cause several health disorders. of interest, the issue of reproductive health impairment of the population wit...
Semen quality appears to have declined in recent decades in some populations, e.g. north-western Europe. At the same time, couple fertility may have increased. Hypotheses are suggested for this apparent inconsistency. Alongside the deterioration of spermatogenesis there is clear evidence of an increase in other related problems, notably testicular cancer. The sharply rising trend in this condit...
STUDY QUESTION What are the reference values for delineating altered somatic cell gene expression from transcript enrichment/dilution in gene expression studies of human spermatogenesis? SUMMARY ANSWER We have designed a crosstable and rule-of-thumb values for different stages of spermatogenic impairment that define the reference cut-off values for altered gene expression in Sertoli and Leydi...
OBJECTIVE To evaluate the expression of the apoptotic genes survivin, Bax and Bcl-2 in vasectomized rabbits and to determine their relation with vasectomy-induced spermatogenic impairment and germ cell apoptosis. MATERIALS AND METHODS Twelve adult rabbits (6-12 months old) were divided into three groups: sham control, unilateral vasectomy or bilateral vasectomy. Six months after vasectomy, te...
Cytochrome P450 aromatase is the key enzyme in estrogen biosynthesis, encoded by CYP19 gene. Impairment of spermatogenesis associated with a decrease in sperm motility and inability to fertilize oocytes in mice due to the lacking of CYP19 was observed. However, it is little known about the CYP19 roles in boar spermatogenesis and fertility. Therefore, the aim of this research was to investigate ...
Mammalian spermatogenesis is a complex hormone-dependent developmental program where interactions between different cell types are finely regulated. Mouse models in which any of the sperm maturation steps are perturbed provide major insights into the molecular control of spermatogenesis. The Twitcher mouse is a model for the Krabbe disease, characterized by the deficiency of galactosylceramidas...
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