The effects of aspirin on N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) -induced urinary bladder lesions, endog enous bladder prostaglandin E2 synthesis, and the metabolism of FANFT by bladder epithelial microsomes were examined. Rats were fed 0.5% aspirin and/or a diet containing 0.1% or 0.2% FANFT. Bladder lesions were observed with light and scanning electron microscopy, and the prost...

The in creas ing in ter est in mo lec u lar sys tems ex hib it ing ESIPT re ac tion has trig gered – due to their broad field of po ten tial ap pli ca tions – an ex ten sive search for prop erly sub sti tuted com pounds with well-tai lored prop er ties. This re view is based on se lected pa pers deal ing with some com monly known ESIPT sys tems mod i fied by spe cific sub stitu ents. The re sul...

Gallstone disease remains one of the most common medical problems leading to surgical in‐ tervention. It occurs in up to 20% of men and 35% of women in Western societies [1, 2]. Ev‐ ery year, more than 500,000 cholecystectomies are performed in the US [3]. The resultant direct and indirect cost of gallbladder disease represents a consumption of ~$6.2 billion an‐ nually in the U.S., constituting...

In the Comoros Islands, the level of malarial endemicity varies greatly from one island to the other, even though the total area (4 islands) covers less than 2 300 km2 and has a population of some 600,000 people only. The epidemiological stratification is based on the diversity of human and physical characterisation. They both determine the presence and the behaviour as well as the size of the ...

With the advances in biotechnology, identification of new therapeutic targets, and better un‐ derstanding of human diseases, pharmaceutical companies and academic institutions have accelerated their efforts in drug discovery. The pipeline to obtain therapeutics often involves target identification and validation, lead discovery and optimization, pre-clinical animal studies, and eventually clini...

Sarcomas In mice were induced by i.m. and s.c. administra tion of 63Niand 36S-labeled nickel subsuifide (Ni3S2), and the fate of the Ni3S2 was studied in tumors and normal tissues during carcinogenesis. Whole-body autoradiography showed a gradual loss of solubilized 63Ni and 35S radioactivity from the site of injection. There was also a loss of nonsolubilized dust particles which appeared to be...

Pools of uridine triphosphate and cytidine triphosphate are greatly (90%) reduced in cultured L1210 cells exposed to N(phosphonacetyl)-L-aspartate (PALA) or pyrazofurin; the con centration of the deoxynucleotides deoxycytidine triphosphate, deoxythymidine triphosphate, and deoxyguanosine triphos phate also decreases, but deoxyadenosine triphosphate pools are enlarged. Associated with these pool...

men who never smoked. A total of 7,316 deaths occurred among regular cigarette smokers, an excess of 2,665 over the 4,651 that would have occurred had the age-specific death rates for smokers been equal to that for nonsmokers. Coronary disease accounted for 52.1% of the excess; lung cancer accounted for 13.5% and cancer of other sites likewise for 13.5% An extremely high association between cig...

derivatives of MBN display striking differences in mutagenicity (19). Of interest because of its structure, toxicity, organ-spe cific carcinogenicity, and mutagenicity of oxidized derivatives, we undertook an extensive investigation of MBN which encom passed toxicity and carcinogenicity testing, pharmacokinetic and metabolic studies, and tissue distribution and persistence evaluations. The latt...

Proliferation of a human metastatic breast cancer cell line derived at the Michigan Cancer Foundation (MCF-7) was stimulated significantly (p < 0.05) by the addition of L-3,3 ,5-triiodothyronine (T3) to the culture medium. An optimal effect was observed near 5 x 10 I0 M. Thyroid hormone receptor was assayed by comparing the radioactive [125I]T3incorporated by MCF-7 cells incu bated in culture w...