Translesion synthesis (TLS) employs low fidelity polymerases to replicate past damaged DNA in a potentially error-prone process. Regulatory mechanisms that prevent TLS-associated mutagenesis are unknown; however, our recent studies suggest that the PCNA-binding protein Spartan plays a role in suppression of damage-induced mutagenesis. Here, we show that Spartan negatively regulates error-prone ...

Purpose: Limited information is available on acute treatments for migraine in elderly patients. Our objective was to evaluate the tolerability and safety of lasmiditan, a serotonin 1F agonist, treatment compared with nonelderly patients, special emphasis cardiovascular-related issues because cardiovascular comorbidities are more common population.Methods: These post hoc analyses evaluated incid...

Legal expertise permits detailed laws to be written and enforced, but individuals with expertise may employ their special knowledge to skew decisions in privately beneficial directions. We illustrate this tradeoff in a simple model, which we use to guide our analysis of the legal system in ancient Athens. Rather than accepting the costs of expertise in return for the benefits, as do most modern...

Cost-optimized Spartan®-7 FPGAs leverage the proven 7 series architecture. Built on the 28nm HPL process and enabled by the Vivado® Design Suite to offer the lowest total power for cost-sensitive products, power-efficient Spartan-7 devices reduce system costs even further by reducing power supply and thermal solution costs without compromising best-in-class performance. Spartan-7 FPGAs provide:...

Although excavated almost 80 years ago, the infants' 'bone well' of the Athenian Agora in Athens, Greece and its contents were never thoroughly evaluated and published, until only recently, when a re-analysis of the whole excavation findings was performed. The well dates back to the third quarter of the 2nd century BC and contained at least 449 infants. The project, which explored the causes of...