Leukotrienes are products of the 5-lipooxygenase pathway of arachidonic acid metabolism that possess potent inflammatory properties. We examined the potential role of this pathway in the decrease in glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) observed in rats after unilateral release of bilateral ureteral obstruction (BUO) of 24 hours duration. Isolated glomeruli fro...

■ EVIDENCE-BASED ANSWER Short-term use of metformin (Glucophage) improves ovulation rates for women with polycystic ovary syndrome (PCOS) (strength of recommendation [SOR]: A, based on systematic reviews of randomized controlled trials [RCT]). Metformin also decreases menstrual irregularities (SOR: B, extrapolated from a systematic review). When added to clomiphene, metformin increases ovulatio...

Analysis of known sulfur oxygenase-reductases (SORs) and the SOR-like sequences identified from public databases indicated that they all possess three cysteine residues within two conserved motifs (V-G-P-K-V-C(31) and C(101)-X-X-C(104); numbering according to the Acidianus tengchongensis numbering system). The thio-modifying reagent N-ethylmaleimide and Zn(2+) strongly inhibited the activities ...

The evaluation of a suspected rotator cuff tear should start with a history and a clinical exam of the shoulder (strength of recommendation [SOR]: B, based on a systematic review of cohort studies). Three clinical test results in particular--supraspinatus weakness, weakness of external rotation, and impingement--or 2 positive tests for a patient older than 60 years were highly predictive of rot...

Sensory over-responsivity (SOR) towards tactile and auditory input can impact children's participation in academic and social activities; however the prevalence of SOR behaviors and their relation to social-emotional problems and competence has not been rigorously studied. This study investigated SOR in a representative sample of elementary school-aged children (n = 925, 50% boys, ages 7-11 yea...

Deficits in sensory modulation have been linked clinically with impaired attention, arousal, and impulsivity for years, but a clear understanding of the relationship between sensory modulation disorders and attention deficit hyperactivity disorder (ADHD) has proven elusive. Our preliminary work suggested that patterns of salivary cortisol and electrodermal responsivity to sensation may be linke...

− The self-organizing relationship (SOR) network was proposed in order to extract a desirable input-output relationship of a target system by using learning vectors with their evaluations. In the execution mode, the SOR network can be used as a fuzzy inference engine. The output of the SOR network depends on matching parameters which correspond to the standard deviation of the Gaussian membersh...

Recently, several proposals for the generalization of Young’s SOR method to the saddle point problem or the augmented system has been presented. One of the most practical versions is the SOR-like method given by Golub et al., [(2001). SOR-like methods for augmented systems. BIT, 41, 71–85.], where the convergence and the determination of its optimum parameters were given. In this article, a ful...

The best approach among studied alternatives to manage a patient with treatment-resistant depression is not clear from the evidence. All of the options reviewed seem to have about a 25% to 30% success rate. Switching to other antidepressants or augmenting with non-antidepressant drugs has the best supporting evidence (strength of recommendation [SOR]: B).1 Adding additional antidepressants (SOR...

It may, depending on the stage of labor and whether the woman has given birth previously. routine amniotomy doesn’t significantly reduce the duration of first-stage labor in either primiparous or multiparous women (strength of recommendation [sOr]: A, systematic review of several randomized, controlled trials [rCTs]); it slightly shortens secondstage labor in primiparous women only (sOr: A, sys...