It has been demonstrated that solid hepatoma lysosomes lack hyaluronidase activity, whereas normal rat liver lyso somes contain a high level of this enzyme. This result was also found with lysosomes from an ascites hepatoma, Walker carcinoma 256, and virally transformed BHK cells. In contrast, 0-yV-acetylglucosaminidase activity was shown to be present in lysosomes from tumor cells, although it...

tandem metacentric compound X chromosome is composed of two X chromoA somes attached to a medially located centromere and arranged in tandem sequence so that the synaptic configuration is a spiral (NOVITSKI 1954). An approximation to the tandem metacentric has been achieved by the construction of an attached-X heterozygous for Zn(l)y4 ( SIDOROV, SOKOLOV and TROFIMOV 1936; STURTEVANT and BEADLE ...

NRPE accumulates and all-trans-ROL levels are tranDean Bok siently decreased due to the inability of all-trans-RAL Department of Neurobiology and Ophthalmology to gain access to the dehydrogenase. School of Medicine The reconstitution studies of Sun et al. (1999) utilized University of California, Los Angeles a large array of potential substrates and demonstrated Los Angeles, California 90095 t...

When ionizing radiation strikes a cell it induces DNA double strand breaks (DSBs). Subsequently, some of the DSBs misrejoin and thus cause alterations in the size distribution of the DNA fragments. We derive a system of non-linear integro-differential equations describing the misrejoining interactions of five classes of DNA fragments, including rings and various types of linear fragments. The f...

correspondence correspondence Left is right, right is wrong T he cover illustration of the August 2009 issue of EMBO reports, although aesthetically pleasing, is unfortunately erroneous and could come as a shock to researchers in the chromatin field. Canonical nucleosomes are indeed left-handed, such as the nucleosomes in the left 'column' of chro-matin fibres on the cover. However, in the righ...