Circulatory levels of growth hormone (GH) were estimated at 0600 h, 1200 h, 1800 h and 2400 h in each of 10 subjects of sea level residents (SLR) in New Delhi (226 m) and in high altitude natives (HAN) settled at an altitude of 3650 m. Both in SLR and HAN the GH secretion showed an identical pattern, the values were lowest at 0600 h and highest at 2400 h. Nevertheless, in HAN the GH levels at d...

A model was developed that allows physicians to individualize GH treatment in children born short for gestational age (SGA) who fail to show spontaneous catch-up growth. Data from children (n = 613) in a large pharmacoepidemiological survey, the KIGS (Pharmacia International Growth Database), or who had participated in clinical trials were used to develop the model. Another group of similar chi...

UNLABELLED BACKGROUNDAIM: In growth disorders, ensuring long-term growth hormone therapy (GHT) remains a challenge that might compromise the clinical outcome. Consequently, strategies aiming at alleviating the burden of daily injection might improve the treatment benefit. The study reported here was performed to assess the ease of use of Norditropin NordiFlex(®) (Novo Nordisk, Princeton, NJ, US...

Growth hormone (GH) transgenes can significantly accelerate growth rates in fish and cause associated alterations to their physiology and behaviour. Concern exists regarding potential environmental risks of GH transgenic fish, should they enter natural ecosystems. In particular, whether they can reproduce and generate viable offspring under natural conditions is poorly understood. In previous s...

Evaluation of the GH secretion using pharmacological GH stimulation tests remains controversial in the diagnosis. The authors present diagnostic problems in recognizing growth hormone deficiency on the basis of literature.

3T3-F442A adipocytes incubated in the presence of growth hormone (GH) showed a transient stimulation of the incorporation of [14C]glucose into cellular lipids, or production of 14CO2 in the first 4 hr. By 48 hr, a significant suppression of glucose metabolism was evident, and persisted for 7 days. Both effects resulted from direct in vitro addition of GH to 3T3 adipocytes. This system therefore...