Solubility prediction of high molecular weight molecules in high-pressure solvents is an interesting field of research. Sometimes the solubility data are not available for several components due to lacking of valid equipments. Therefore, an accurate prediction technique can help the researchers. According to the literature, the simple Equations of State (EoSs) such as Soave-Redlich-Kwong (SRK),...

       Purpose of this study was to investigate the effect of the presence of the water soluble polymers viz HPMC, PVP and PEG 6000 on aqueous solubility and complexation abilities of felodipine with or without presence of β-cyclodextrin (βCD) and HPβCD by phase solubility studies. The data revealed the initial increase in drug solubility followed by plateau in t...

Solubility of organic compounds in DMSO is an important issue for commercial and academic organizations handling large compound collections or performing biological screening. In particular, solubility data are critical for the optimization of storage conditions and for the selection of compounds for bioscreening compatible with the assay protocol. Solubility is largely determined by the solvat...

Aqueous solubility of a drug/drug candidate is essential data in drug discovery, and an in silico method for predicting the aqueous solubility of drug candidates provides a valuable tool to speed up the process of drug discovery and development. This paper describes a simple quantitative structure property relationship (QSPR) model for predicting the aqueous solubility of drugs which is validat...

The apparent solubility controls the initial stage of supercritical fluid extraction of natural products, which is most important for the process economics. Based on the literature, data on CO2 apparent solubility of volatile substances from different matrices as leaves, flowers, rhizomes and seeds were collected and compared with their thermodynamic solubility. The adsorption isotherm derived ...

The Solubility Data project (SDP) has as its aim a comprehensive review of published data for solubilities of gases, liquids and solids in liquids or solids. Data of suitable precision are compiled for each publication on data sheets in a uniform format. The data for each system are evaluated and, where data from independent sources agree sufficiently, recommended values are proposed. The evalu...

A rapid throughput equilibrium solubility measurement is described. The method utilizes central liquid storage where compounds are stored as 10mM solution in dimethyl sulfoxide (DMSO). The DMSO is subsequently removed to generate solid like material used for solubility measurement. A full range of available technologies is used including automated liquid handling, automated data collection usin...

The Solubility Data project (SDP) has as its aim a comprehensive review of published data for solubilities of gases, liquids and solids in liquids or solids. Data of suitable precision are compiled for each publication on data sheets in a uniform format. The data for each system are evaluated and, where data from independent sources agree sufficiently, recommended values are proposed. The evalu...

The accurate prediction of solubility of drug-like molecules is difficult, and perhaps a satisfactory general model is not yet available. The most cited challenge to good prediction has been the lack of enough highquality and drug-relevant solubility data that adequately cover the chemical space of drugs. This review addresses data quality in solubility measurement. Specifically, the “gold stan...

The present work concerns with an investigation on the solubility of cis,cis-muconic acid dissolution in different polar solvents by characterizing and modeling the dissolution as a function of temperature. Water, ethanol, 2-propanol and acetic acid have been investigated as solvents in the range temperatures from a 298.15 to 348.15 K. Owing to the absence of cis,cis-muconic acid solubility...