Background and objectives: Carvacrol is one of the main pharmacologically active components of Thymus vulgaris essential oil which has shown several therapeutic effects. There are few works regarding the formulation of essential oils as oral solid dosage forms due to their liquid nature, stability and technical problems. The aim of this study was to combine the solid-d...

in this research, zeolite-tio2 nanocomposite was prepared for degradation of dibenzothiophene as a typical aromatic organosulfur compound of transportation fuels.the synthesized tio2 was immobilized on the surface of clinoptilolite by solid state dispersion (ssd) method. the nanocomposite was then characterized by xrd, ftir, tem and sem techniques. photodegradation of dibenzothiophene in n-hexa...

in this paper cufe2o4, nanocrystalline powders were prepared. also, the supported cu ferrite was obtained by impregnation of the supports with cu and fe nitrates solutions, for calcination temperature 450 ºc. the samples were characterized by x-ray powder diffraction (xrd) and fourier transform-infrared spectroscopy (ft-ir). photocatalytic degradation of acid red 206 in water was studied. cufe2...

cefquinome sulfate (cs) is a fourth-generation cephalosporin, which has been developed solely for veterinary use. it shows potent antibacterial activity against a broad spectrum of bacterial species. however, cefquinome is susceptible to hydrolysis, which limiting its clinical employment efficacies to some extent. so, in this study, to increase cefquinome sulfate biological half-life, a novel c...

The present study was designed to improve the solubility and hence enhance the dissolution of hydrophobic drug Atorvastatin calcium (ATC) in order to increase its bioavailability. Solid dispersion of atorvastatin calcium using carrier PEG 4000 was formulated in different ratios by conventional fusion and microwave induced fusion method. In particular, the Microwave technology has been considere...

aim: to enhance the aqueous solubility of olanzapine by using the solid dispersion technique. solid dispersions of olanzapine were prepared by the dispersion method using using pgs and ssg as carriers. drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...

ibuprofen solid dispersions were prepared by the solvent and fusion-solvent methods using polyethylene glycol (peg), polyvinylpyrrolidone (pvp), eudragit rs po, eudragit rl po and hydroxypropylmethylcellulose (hpmc) as carriers to improve physicochemical characteristics of ibuprofen. the prepared solid dispersions were evaluated for the flowability, solubility characteristics and dissolution be...

The aim of present work was to optimize the effect of Ethyl Cellulose (EC) and Polyvinyl Pyrrolidone (PVP) concentration in extended release solid dispersion of Glibenclamide using combination of hydrophilic and hydrophobic polymers such as Polyvinyl Pyrrolidone and Ethyl cellulose. The advantage of solid dispersion technique provides a unique approach to particle size reduction and increased r...

The objective of present work is to investigate the enhancement of dissolution profile for oral delivery of Fexofenadine Hydrochloride (FH) through solid dispersion (SD) technique by the method of solvent evaporation. The SD was prepared by using ethanol as a solvent. Tablets were formulated containing solid dispersion of FH and compared with tablets of same formula without solid dispersion of ...