Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using hot melt extrusion. Since ITZ possesses a water solubility of less than 1ng/mL, the aim of this work was to enhance the aqueous solubility of ITZ, and thereby improve its bioavailability. The three for...

The neurotransmitter glutamate mediates excitatory synaptic transmission by gating ionotropic glutamate receptors (iGluRs). AMPA receptors (AMPARs), a subtype of iGluR, are strongly implicated in synaptic plasticity, learning, and memory. We previously discovered two classes of AMPAR auxiliary proteins in C. elegans that modify receptor kinetics and thus change synaptic transmission. Here, we h...

It has been shown that cat soleus (SOL) forces remain nearly constant despite increases in electromyography (EMG) activity for increasing speeds of locomotion, while medial gastrocnemius (MG) forces and EMG activity increase in parallel. Furthermore, during jumping, average cat SOL forces decrease, while average EMG activity increases dramatically compared with walking conditions. Finally, duri...

We carried out a study of the clinical courses of 70 untreated patients with primary hepatocellular carcinoma (HCC) in order to evaluate their survival period and the prognostic factors. The median survival was two months. We evaluated ten variables of biochemical parameters and findings of hepatic scintigraphy. Among them, six variables were chosen by univariate analysis. They were serum bilir...

................................................................................... viii CHAPTER 1. INTRODUCYION ........................................................... 1 1.1 Motivation ................................................................................. 1 1.2 Outline ..................................................................................... 2 CHAPTER 2. SOL-GEL PHOT...

The tributylphenyltin (TBPT)-encapsulated resorcinol (R)-formaldehyde (F) sol was prepared inside the micelles of cetyltrimethylammonium bromide (CTAB). This core-shell-type sol was polymerized and further carbonized to obtain nanosized Sn-encapsulated spherical hollow carbon. The size of spherical hollow carbon and Sn metal particles was controllable by changing the R/CTAB or TBPT/CTAB mole ra...

Mn-based catalysts enable high NO x conversion in the selective catalytic reduction of NO x with NH3. Three catalyst-production methods, namely, co-precipitation, impregnation, and sol-gel, were used in this study to determine the optimum method and parameters. The maximum catalytic activity was found for the catalyst prepared by sol-gel with a 0.5 Mn/Ti ratio. The denitrification efficiency us...

Pervasive computing is concerned with making our lives easier through digital environments that are sensitive, adaptive, and responsive to human needs. Different works have shown the suitability of the agent paradigm for the development of pervasive applications. However, so far there is not a dominant approach adopted for the development of agent-based pervasive systems. In particular, two key...

The self-assembly of low molecular weight gelators to form gels has enormous potential for cell culturing, optoelectronics, sensing, and for the preparation of structured materials. There is an enormous “chemical space” of gelators. Even within one class, functionalised dipeptides, there are many structures based on both natural and unnatural amino acids that can be proposed and there is a need...

In this paper,the preparation of nano silica sol was used TEOS hydrolysis. Silica sol was used to compound the SiO2 sol / polyacrylate with acrylate monomer emulsion polymerization, the effect of sol amount and feeding methods of polyacrylate stability and other property of SiO2 / polyacrylate were studied.