BACKGROUND The increase in relative biological effectiveness (RBE) of proton beams at the distal edge of the spread out Bragg peak (SOBP) is a well-known phenomenon that is difficult to quantify accurately in vivo. For purposes of treatment planning, disallowing the distal SOBP to fall within vulnerable tissues hampers sparing to the extent possible with proton beam therapy (PBT). We propose th...

Carbon ions/Carbon-therapy/Biologieal treatment planlRBE. Duc to the RBE variations, the carbon-ion doses (in Gy) are no longer sufficient to moniter adequately the biological effect of these radiations. Therefore, "RBE dose weighting factors" WRBE allowing for the RBE variations with energy, dose and biological system have to be introduced in the treatment plans in order to provide the physici...

BACKGROUND Recent studies in eye plaque brachytherapy have shown a considerable difference between the dosimetric results using water phantom and a model of human eye containing realistic materials. In spite of this fact, there is a lack of simulation studies based on such a model in proton therapy literatures. In the presented work, the effect of utilizing an eye model with ocular media on pro...

Background: Recent studies in eye plaque brachytherapy have shown a considerable difference between the dosimetric results using water phantom and a model of human eye containing realistic materials. In spite of this fact, there is a lack of simulation studies based on such a model in proton therapy literatures. In the presented work, the effect of utilizing an eye model with ocular media on pr...

PURPOSE A method was developed to convert clinically prescribed RBE (Relative Biological Effectiveness)-weighted doses from the approach used at the Heavy-Ion Medical Accelerator (HIMAC) at the National Institute of Radiological Science, Chiba, Japan, to the LEM (Local Effect Model)-based TReatment planning for Particles (TRiP98) approach used in the pilot project at the GSI Helmholtzzentrum, D...

background: recent studies in eye plaque brachytherapy have shown a considerable difference between the dosimetric results using water phantom and a model of human eye containing realistic materials. in spite of this fact, there is a lack of simulation studies based on such a model in proton therapy literatures. in the presented work, the effect of utilizing an eye model with ocular media on pr...