Escherichia coli clonal group A (CGA) was first reported in 2001 as an emerging multidrug-resistant extraintestinal pathogen. Because CGA has considerable implications for public health, we examined the trends of its global distribution, clinical associations, and temporal prevalence for the years 1998-2007. We characterized 2,210 E. coli extraintestinal clinical isolates from 32 centers on 6 c...

Batracylin (8-aminoisoindolo[1,2-b]quinazolin-12(10 H)-one; BAT) is a heterocyclic amine that exhibits antitumor activity in a number of in vivo and in vitro models. The acetyl product has been implicated in BAT toxicity in animals, cells, and bacteria. The ability of human N-acetyltransferase (NAT) to form this product was investigated. Nine human liver samples were analyzed for NAT1 and NAT2 ...

Carbamazepine (CBZ) is the most frequently detected pharmaceutical residues in aquatic environments effluent by wastewater treatment plants. Batch and column experiments were conducted to evaluate removal of CBZ from ultra-pure water plant (WWTP) using raw zeolitic tuff (RZT) surfactant modified zeolite (SMZ). Point zero net charge (pHpzc), X-ray diffraction (XRD), fluorescence (XRF), Fourier T...

Sulfonamides display a wide variety of pharmacological activities. Sulfamethazine [abbreviated as SMZ; systematic name 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide], one of the constitutents of the triple sulfa drugs, has wide clinical use. Pharmaceutical solvates are crystalline solids of active pharmaceutical ingredients (APIs) incorporating one or more solvent molecules in the cr...

This study evaluated the influence of temporal variation on the occurrence, fate, and transport of tylosin (TYL) and sulfamethazine (SMZ); antibiotics commonly used in swine production. Atrazine (ATZ) was used as a reference analyte to indicate the agricultural origin of the antibiotics. We also assessed the impact of season and hydrology on antibiotic concentrations. A reconnaissance study of ...

Zeolitic tuffs are found in different parts of the world. Iranian zeolite is a low-cost material that can be frequently found in nature. Surfactant-modified zeolite (SMZ) can be used for the adsorption of natural organic matter (NOM) from aqueous solutions. The adsorption study was conducted to evaluate the adsorption capacity of SMZ; furthermore, the effects of contact time, initial pH, and th...

Biliary atresia is progressive fibro-inflammatory cholangiopathy of young children. Central to pathogenic mechanisms of injury is the tissue targeting by the innate and adaptive immune cells. Among these cells, neutrophils and the IL-8/Cxcl-8 signaling via its Cxcr2 receptor have been linked to bile duct injury. Here, we aimed to investigate whether the intestinal microbiome modulates Cxcr2-dep...

Biosolids, materials resulting from domestic sewage treatment, are surface applied to forest soils to increase nutrient availability. Retaining streamside management zones (SMZs) can limit nutrient pollution of streams. We delineated 15 m SMZs along three intermittent streams in an 18-year-old Pinus taeda L. plantation. We applied biosolids outside the SMZ on one side of each of the streams mai...

The electrochemical oxidation of sulfamethazine (SMZ) has been studied at a multi-walled carbon nanotubes modified glassy carbon electrode (MWCNT-GCE) by cyclic voltammetry. This modified electrode (MWCNT-GCE) exhibited excellent electrocatalytic behavior toward the oxidation of SMZ as evidenced by the enhancement of the oxidation peak current and the shift in the anodic potential to less posit...

We set out to improve understanding of the effectiveness of streamside management zones (SMZs) for protecting water quality in landscapes dominated by agriculture. We conducted a paired-catchment experiment that included water quality monitoring before and after the establishment of a forest plantation as an SMZ on cleared farmland that was used for extensive grazing. In a second study, we moni...