Brinker is the key target protein of the Drosophila Decapentaplegic morphogen signalling pathway. Brinker is widely expressed and can bind with DNA. NMR spectra suggest that apo-Brinker is intrinsically unstructured and undergoes a folding transition upon DNA-binding. However, the coupled mechanism of binding and folding is poorly understood. Here, we performed molecular dynamics (MD) simulatio...

The concepts of cumulative distribution function and empirical distribution function are investigated for fuzzy random variables. Some limit theorems related to such functions are established. As an application of the obtained results, a method of handling fuzziness upon the usual method of Kolmogorov–Smirnov one-sample test is proposed. We transact the α-level set of imprecise observations in ...

Divergence date estimates are central to understand evolutionary processes and depend, in the case of molecular phylogenies, on tests of molecular clocks. Here we propose two non-parametric tests of strict and relaxed molecular clocks built upon a framework that uses the empirical cumulative distribution (ECD) of branch lengths obtained from an ensemble of Bayesian trees and well known non-para...

BACKGROUND To address the challenging problem of selecting distinguished genes from cancer gene expression datasets, this paper presents a gene subset selection algorithm based on the Kolmogorov-Smirnov (K-S) test and correlation-based feature selection (CFS) principles. The algorithm selects distinguished genes first using the K-S test, and then, it uses CFS to select genes from those selected...

many commonly used statistical methods require that the population distribution be nearly normal. unfortunately, in some papers the one-sample kolmogorov-smirnov test has been used for testing normality while the assumptions of applying this test are not satisfied. to conduct this test, it is assumed that the population distribution is fully specified. in practical situation where the mean and ...

We compare the eigenvalue spectra of the Dirac operator from a simulation with two mass degenerate dynamical chirally improved fermions with Random Matrix Theory. Comparisons with distribution of k−th eigenvalues (k = 1, 2) in fixed topological sectors (ν = 0, 1) are carried out using the Kolmogorov-Smirnov test. The eigenvalue distributions are well described by the RMT predictions. The match ...