نتایج جستجو برای: smiles rearrangement

تعداد نتایج: 28600  

2015
Roger R. Nani James B. Shaum Alexander P. Gorka Martin J. Schnermann

New synthetic methods to rapidly access useful fluorophores are needed to advance modern molecular imaging techniques. A new variant of the classical Smiles rearrangement is reported that enables the efficient synthesis of previously inaccessible C4'-O-alkyl heptamethine cyanines. The key reaction involves N- to O-transposition with selective electrophile incorporation on nitrogen. A representa...

Journal: :Angewandte Chemie 2021

Intramolecular nucleophilic aromatic substitution (Truce–Smiles rearrangement) of the anions 2-benzyl benzanilides leads to triarylmethanes in an operationally simple manner. The reaction succeeds even without electronic activation ring that plays role electrophile SNAr reaction, being accelerated instead by preferred conformation imposed tertiary amide tether. substituent product may be remove...

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