نتایج جستجو برای: smarca4 gene
تعداد نتایج: 1141500 فیلتر نتایج به سال:
The E2F6 protein functions as an Rb-independent repressor of gene transcription. We have previously provided evidence suggesting a role for E2F6 in repression of E2F-responsive genes at S phase. Here, we have identified BRG1, the ATPase subunit of the SWI/SNF chromatin-remodeling complex, as an E2F6 interacting protein. Immunoprecipitation experiments demonstrate that BRG1 binds specifically to...
Chromatin remodeling has been newly established as an important cancer genome characterization and recent exome and whole-genome sequencing studies of hepatocellular carcinoma (HCC) showed that recurrent inactivating mutations in SWI/SNF subunits involved in the molecular basis of hepatocarcinogenesis. To test the hypothesis that genetic variants in the key subunits of SWI/SNF complexes may con...
The mammalian SWI/SNF chromatin-remodeling complex is essential for the multiple changes in gene expression that occur during differentiation. However, the basis within the complex for specificity in effecting positive versus negative changes in gene expression has only begun to be elucidated. The catalytic core of the complex can be either of two closely related ATPases, BRM or BRG1, with the ...
ATP-dependent chromatin-remodeling complexes contribute to the proper temporal and spatial patterns of gene expression in mammalian embryos and therefore play important roles in a number of developmental processes. SWI/SNF-like chromatin-remodeling complexes use one of two different ATPases as their catalytic subunit: brahma (BRM, also known as SMARCA2) and brahma-related gene 1 (BRG1, also kno...
مقدمه : بیماری عروق کرونر (cad) یکی از علل اصلی مرگ و میر و ناتوانی در سراسر جهان است بر هم کنش بین عوامل ژنتیکی و محیط استعداد افراد برای ابتلا به cad را تعیین می کند . لذا هدف از این مطالعه بررسی ارتباط بین پلی مورفیسم های شایع در ژنهای ldlr,smarca5 و csk9 با خطر ابتلا به بیماری عروق کرونر و بررسی ارتباط آنها با شدت گرفتاری عروق ( تعداد رگ ) در مبتلایان به این بیماری است . مواد و روش ها: در ...
Subunits of the SWI/SNF chromatin remodeling complex are frequently mutated in human cancers leading to epigenetic dependencies that are therapeutically targetable. The dependency on the polycomb repressive complex (PRC2) and EZH2 represents one such vulnerability in tumors with mutations in the SWI/SNF complex subunit, SNF5; however, whether this vulnerability extends to other SWI/SNF subunit ...
Preoperative radiochemotherapy is a promising therapeutic method for locally advanced rectal cancer patients. However, the response of colorectal (CRC) patients to preoperative radiotherapy varies widely. In this study, we aimed identify novel biomarkers that could predict tumors treatment using systems biology approach. We applied Weighted Gene Co-Expression Network Analysis construct co-expre...
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