Designing ideal radiopharmaceuticals for use as bone pain palliatives require the use of a moderate energy β emitter with a stable carrier molecule. Cyclic polyaminophosphonate ligands are known to form complexes with higher thermodynamic stability and kinetic inertness. The present study therefore envisages the use of a few moderate energy β emitters, viz. Lu (T1/2 = 6.71 d, Eβmax= 497 keV), S...

The characterization of a new class of hydrophilic liver-targeted agents for gamma-scintigraphy and MRI, consisting, respectively, of [(153)Sm](3+) or Gd(3+) complexes of DOTA monoamide or bisamide linked glycoconjugates (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), is reported. In vitro studies show high uptake of radiolabeled [(153)Sm]-DOTAGal(2) by the human hepatocyte c...

The nuclear level densities (NLDs) and the $\ensuremath{\gamma}$-ray strength functions ($\ensuremath{\gamma}\mathrm{SFs}$) of $^{153,155}\mathrm{Sm}$ have been extracted from ($d,p\ensuremath{\gamma}$) coincidences using Oslo method. experimental NLD $^{153}\mathrm{Sm}$ is higher than $^{155}\mathrm{Sm}$, in accordance with microscopic calculations. $\ensuremath{\gamma}\mathrm{SFs}$ are fair a...

Introduction: Involvement of the skeleton can cause an excruciating pain in two-thirds of terminal patients with a history of malignancy. Due to several limitations of other therapies, such as analgesics, bisphosphonates, chemotherapy, hormonal therapy and external beam radiotherapy; bone-seeking radiopharmaceuticals have an important role in palliation of pain from bone metastases. Although th...

PURPOSE Dosimetric accuracy depends directly upon the accuracy of the activity measurements in tumors and organs. The authors present the methods and results of a retrospective tumor dosimetry analysis in 14 patients with a total of 28 tumors treated with high activities of (153)Sm-ethylenediaminetetramethylenephosphonate ((153)Sm-EDTMP) for therapy of metastatic osteosarcoma using planar image...

Highly branched noble metal nanostructures are highly attractive for catalytic applications owing to their specific physical and chemical properties. In this work, three-dimensional highly branched palladium tetrapods (Pd-THBTs) have been constructed in the presence of polyvinylpyrrolidone (PVP) through one-step hydrothermal reduction of ethylenediamine-tetramethylene phosphonate-palladium(II) ...

introduction: involvement of the skeleton can cause an excruciating pain in two-thirds of terminal patients with a history of malignancy. due to several limitations of other therapies, such as analgesics, bisphosphonates, chemotherapy, hormonal therapy and external beam radiotherapy; bone-seeking radiopharmaceuticals have an important role in palliation of pain from bone metastases. although th...

PURPOSE The aim of this study was to evaluate the degree of metastatic bone pain palliation and medullar toxicity associated with samarium-153-EDTMP treatment. METHODS Seventy-three patients with metastatic bone pain having previously undergone therapy with samarium-153-EDTMP (1 mCi/kg) were retrospectively evaluated. Routine follow-up included pain evaluation and blood counts for 2 months af...