Various gene signatures of chemosensitivity in breast cancer have been discovered. One previous study employed t-test to find a signature of 31 probe sets (27 genes) from a group of patients who received weekly preoperative chemotherapy. Based on this signature, a 30-probe set diagonal linear discriminant analysis (DLDA-30) classifier of pathologic complete response (pCR) was constructed. In th...

In rodents, soluble leptin receptor (SLR) may be generated by alternative splicing of ObR mRNA and/or as a cleavage product of ObR membrane-anchored receptors. In this study, we investigated the contribution of both processes on the generation of SLR in 3-, 8-, and 24-month-old Wistar rats fed ad libitum (AL) or under food restriction (FR). To this end, we determined serum SLR levels and analyz...

Terminally misfolded proteins are selectively recognized and cleared by the endoplasmic reticulum-associated degradation (ERAD) pathway. SEL1L, a component of the ERAD machinery, plays an important role in selecting and transporting ERAD substrates for degradation. We have determined the crystal structure of the mouse SEL1L central domain comprising five Sel1-Like Repeats (SLR motifs 5 to 9; he...

Streptococcus pyogenes is an important human pathogen and surface structures allow it to adhere to, colonize and invade the human host. Proteins containing leucine rich repeats (LRR) have been identified in mammals, viruses, archaea and several bacterial species. The LRRs are often involved in protein-protein interaction, are typically 20-30 amino acids long and the defining feature of the LRR ...

BACKGROUND Normal displacement of the conus medullaris with unilateral and bilateral SLR has been quantified and the "principle of linear dependence" has been described. PURPOSE Explore whether previously recorded movements of conus medullaris with SLRs are i) primarily due to transmission of tensile forces transmitted through the neural tissues during SLR or ii) the result of reciprocal move...

PURPOSE To evaluate a low-rank decomposition method to reconstruct down-sampled k-space data for the purpose of tumor tracking. METHODS AND MATERIALS Seven retrospective lung cancer patients were included in the simulation study. The fully-sampled k-space data were first generated from existing 2-dimensional dynamic MR images and then down-sampled by 5 × -20 × before reconstruction using a Ca...

A core assumption underlying mental chronometry is that more complex tasks increase cortical processing, prolonging reaction times. In this study we show that increases in task complexity alter the magnitude, rather than the latency, of the output for a circuit that rapidly transforms visual information into motor actions. We quantified visual stimulus-locked responses (SLRs), which are changes...

In the last decade, we have been witnessing a rapid development of the constellations of Global and Regional Navigation Satellite Systems (GNSS/RNSS). Besides the well-known GPS and GLONASS, newly developed systems such as Galileo, BeiDou, QZSS and NAVIC have become increasingly important. All satellites of new GNSS are equipped with laser retroreflector arrays (LRA) dedicated to Satellite Lase...

ZigBee is defined to support low-rate wireless personal area networks (WPANs). It supports tree and mesh routing. Observing that both routing mechanisms have their pros and cons, this paper proposes a Self-Learning Routing (SLR) protocol, which inherits the low overhead of tree routing and the path efficiency of mesh routing. SLR contains an overhearing and a caching mechanism. It does not rely...

This contribution reassesses progress in the development of satellite laser ranging (SLR) technology and its scientific and societal applications in South Africa. We first highlight the current global SLR tracking stations within the framework of the International Laser Ranging Service (ILRS) and the artificial satellites currently being tracked by these stations. In particular, the present wor...